颅内转移瘤195例临床报告

A Clinical Analysis of 195 Cases with Intracranial Metastatic Tumors

背景与目的:颅内转移瘤在临床治疗上依然存在很多难点,患者预后差。本文总结分析颅内转移瘤患者的临床特征、肿瘤来源、治疗方式及其疗效等相关问题。方法:回顾性分析1976年1月至2006年12月我科共收治的颅内转移瘤患者共195例,分别在患者一般情况、临床表现、影像学特点、原发肿瘤情况、治疗方式、病理诊断及患者生存期等方面予以归纳总结。结果:脑转移瘤发病率呈现上升趋势,多为中年发病,大部分为肺癌脑转移,MRI扫描+Gd-DPTA增强可明显增加脑转移瘤的诊断率。外科手术、立体定向放射治疗、全脑放疗及化疗等综合治疗可明显的改善症状,对于单发或者较少多发转移灶的患者可延长其生存期;但对于转移灶较多或粟粒型转移的患者还没有能够明显延长生存期的治疗方法。结论:脑转移瘤在治疗上应主要以改善患者生存质量为主,采取综合治疗措施,以延长患者生存期。

BACKGROUND＆OBJECTIVE： Management of patients with intracranial metastatic tumors is still difficult, and the prognosis is poor. In this study we summarized the clinical features, tumor origin, treatment and curative effects of intraeranial metastatic tumors. METHOD： Clinical data of 195 cases with intraeranial metastatic tumors hospitalized in our department from Junuary 1976 to December 2006 were retrospectively analyzed. RESULTS： The incidence of intraeranial metastatic tumors increased in recent years. A majority of patients were middle-aged and the metastases commonly originated from lung cancer. Enhanced MRI scanning was important for the accurate diagnosis of brain metastases. Surgical intervention, stereotaetie radiotherapy, whole-brain radiation therapy and chemotherapy were effective to improve the patients＇ quality of life and overall survival. But the prognosis of patients with wide-spread brain metastases was still poor, CONCLUSION： Muhidiseiplinary treatment may improve the quality of life and overall survival in selected patients with brain tumors.