普罗布考对维持性血液透析患者氧化应激的影响

Effect of probucol on oxidative stress in maintenance hemodialysis patients

目的观察口服普罗布考对维持性血液透析(MHD)患者氧化应激的影响。方法选择20例透析时间超过3个月的MHD患者,口服普罗布考0.5 g/次,2次/d,服药8周。观察用药前后血浆丙二醛(MDA)、循环晚期氧化蛋白产物(AOPP)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-Px)的含量。选择20例年龄、性别匹配的健康人作为对照组。结果与对照组比较,MHD患者血清MDA、AOPP含量升高(P<0.05),SOD、GSH-Px含量降低(P<0.05);应用普罗布考8周后,MHD患者血清MDA、AOPP含量明显降低(P<0.05),SOD、GSH-Px含量明显升高(P<0.05)。结论普罗布考明显改善MHD患者的氧化应激水平,短期应用无明显不良反应。

Objective To observe the effect of probucol on oxidative stress in maintenance hemodialysis （MHD） patients. Methods 20 MHD patients （MHD group）and 20 healthy person （control group）were involved in the study. Patients in experimental group were administered probucol 0.5g, twice a day for 8 weeks. Levels of malondi- aldehyde （MDA） , advanced oxidation protein product （AOPP） , superoxide dismutase （ SOD ） and activity of glutathione peroxidase （GSH-PX）in plasma were measured at the beginning and the end of administering probucol. Results Compared with control group, the plasma levels of MDA and AOPP were higher, SOD and GSH-PX were lower in MHD group （P〈0.05）. After administering probucol, the plasma levels of MDA and AOPP decreased significantly （P〈0.05）, the plasma levels of SOD and GSH-PX increased （ P 〈 0. 05 ）. Conclusion Short-term administering probucol can ameliorated oxidative stress in MHD patients without apparent side effect.