脉冲电磁场与运动对骨质疏松大鼠骨密度的影响

Effects of Pulsed Electromagnetic Field and Exercise on Bone Mineral Density of Rats with Osteoporosis

目的探讨脉冲电磁场(PEMFs)或(和)运动对维甲酸形成的骨质疏松模型大鼠的面积骨密度(aBMD)和体积骨密度(vBMD)的影响。方法将100只3月龄健康雌性SD大鼠随机分为PEMFs组、运动组、运动+PEMFs组、骨质疏松组和健康对照组,每组20只。除健康对照组外,其余各组以维甲酸灌胃法建立骨质疏松模型。造模成功后按不同方案对各组大鼠进行干预,分别在治疗第4周、6周、8周检测相应的指标。结果与骨质疏松组相比,PEMFs组、运动组、运动+PEMFs组的骨密度分别在治疗第6周、第4周、第4周开始增加(P<0.05),运动+PEMFs组第6周、第8周的骨密度与PEMFs组和运动组相比无显著性差异(P>0.05)。结论PEMFs和运动均能有效增加骨质疏松大鼠的骨密度,但PEMFs的起效时间晚于运动。

Objective To observe the effects of pulsed electromagnetic field （PEMFs） or/and exercise on the area bone mineral density （aBMD） and volume bone mineral density （vBMD） of rats with osteoporosis induced by tretinoin gastric perfusion. Methods 100 female SD rats were randomly divided into 5 groups with 20 rats in each group： PEMFs group, exercise group, PEMFs plus exercise group, osteoporosis group and healthy control group. Except for the healthy control group, the osteoporosis models of other 4 groups were built by tretinoin gastric perfusion. After the building of models, each group was intervened with different treatment. In the 4th, 6th and 8th week after treatment, relevant results of aBMD and vBMD were tested. Results Compared with the osteoporosis group, the BMD of the rats of PEMFs group, exercise group, PEMFs plus exercise group significantly increased significantly （ P〈0.05） in the 6th week, 4th week and 4th week after treatment respectively. In the 6th and 8th week, there was no significant differences among the PEMFs plus exercise group, the exercise group and the PEMFs group （ P〉0.05）. Conclusion PEMFs can increase the BMD of the rats with osteoporosis as well as exercise. PEMFs takes effect slower than exercise.