术中应用甲基强的松龙对脊髓型颈椎病疗效的影响

Effect of Methylprednisolone on Surgical Treatment of Cervical Spondylotic Myelopathy

目的探讨术中应用甲基强的松龙(MP)对脊髓型颈椎病患者脊髓减压术后神经功能恢复的影响。方法114例行颈椎前路减压治疗脊髓型颈椎病患者分为MP组和对照组,每组57例。MP组于脊髓减压前30min给予MP20mg/kg体重快速静滴;对照组仅行前路减压手术。观察两组患者术后的并发症。术前及术后1d、2周、6个月分别用美国脊髓损伤协会(ASIA)评分标准评定患者的神经功能。结果MP组在术后1d、2周和6个月时的脊髓功能康复情况好于对照组(P<0.05),并发症发生率两组患者间的差异无显著性意义(P>0.05)。结论术中应用MP能促进脊髓型颈椎病患者脊髓减压术后神经功能的康复。

Objective To investigate the effects of methylprednisolone （MP） on the recovery of postoperative neurological functions due to cervical spondylotic myelopathy. Methods 114 patients with cervical spondylotic myelopathy were divided into the MP group and the control group with 57 cases in each group. The cases of the MP group were treated with MP （20 mg/kg, iv） 30 min prior to the decompression. Those of the control group underwent anterior decompression only. The complications of patients in two groups were compared. The neurological functions of all patients were graded according the ASIA score system preoperatively and at 1st day, 2nd week and 6th month postoperatively. Results Compared with the control group, the neurological functions of the cases in the MP group improved significantly after operation （P〈0.05）. Conclusion For patients with cervical spondylotic myelopathy, MP used during operation can improve postoperative neurological function recovery.