超临界流体技术制备三棕榈酸甘油酯微粒

Preparation of Tripalmitin Micronization by Supercritical Fluids Technique

利用气体饱和溶液微粒形成技术实验装置,分别用超临界N2和超临界CO2制备三棕榈酸甘油酯微粒,探讨压力、温度以及喷嘴大小等工艺参数对微粒(粒径、粒径分布和形貌)的影响。结果表明:N2辅助过程得到的微粒基本为球状;预膨胀压力越高,粒径越小,粒径分布越窄;100μm喷嘴下制得的微粒粒径最小,且分布较均匀。CO2辅助过程得到的微粒部分为球状,部分为针状和片状;预膨胀压力越高,粒径越小,粒径分布越窄;喷嘴直径大小对微粒平均粒径及粒径分布影响不大;预膨胀温度升高,颗粒的粒径稍微增大。CO2辅助过程得到的微粒粒径比N2辅助过程得到的微粒粒径稍大,但两者的粒径分布相差不大。

Generation of tripalmitin microparticles from its melts was investigated by using both supercritical CO2 and supercritical N2. The effects of various operating conditions, such as the pre-expansion pressure, preexpansion temperature, and nozzle size on the particle morphology, particle size and particle size distribution （PSD） were investigated. Results showed that microspheres were obtained from the N2-assisted process, the particle size decreased and PSD narrowed with the increasing of the pre-expansion pressure, nozzle size showed no obvious effect on the microparticles, and pre-expansion temperature should be less than 72 % to obtain solid particles. From the CO2-assited process, spherical, lamellate and needle-like particles were obtained, the particle size decreased, PSD narrowed with the increasing of the pre-expansion pressure, nozzle size showed no obvious effect on the particles and the pre-expansion temperature slightly increased the average size of particles. Particles＇ PSD from supercritical CO2 was close to that from supercritical N2.