摘要
以硫脲为原料、溴代丙酮酸乙酯为试剂,无溶剂合成出2-氨基噻唑-4-甲酸乙酯,随后经DMSO、亚硝酸钠高温重氮化法得到2-溴噻唑-4-甲酸乙酯,最后经碳酸钾-甲醇溶液皂化得到目标2-溴噻唑-4-甲酸。各步化合物经熔点、高效液相、质谱、氢核磁谱等分析手段,验证结构符合及纯度。
Ethyl 2-amino-thiazole-4-carboxylate was synthesized with thiourea and ethyl bromppyruvate by solvent-free. Then it was reacted with DMSO and sodium nitrite by diazotization in high temperature to form ethyl 2-bromothiazole-4-carboxylate. Finally, the 2-bromo-thiazole-4-carboxy acid was synthesized by ethyl 2- bromothiazole-4-earboxylate through saponification in potash-methanol solvent. The compounds were determined by means of melting point measurement, IR, MS（ESI）, ^1H-NMR. The result showed exact structure and purity.
出处
《广州化工》
CAS
2009年第2期94-95,共2页
GuangZhou Chemical Industry
关键词
2-溴噻唑-4-甲酸
无溶剂
重氮化
皂化
2-bromo-thiazole-4-carboxylic acid
solvent-free
diazotization
saponification
