氨酚羟考酮片治疗腰腿痛的临床应用评价

Analgesic effect of oxycodone-acetaminophen tablet in treatment of backleg pain

目的:观察氨酚羟考酮片治疗腰腿痛的镇痛效果并与曲马多缓释片比较。方法:100例腰腿痛患者按随机数字法分为氨酚羟考酮组(n=54)和曲马多组(n=46)。分别服用氨酚羟考酮片及盐酸曲马多片进行治疗。观察治疗前后数字评分量表(numeric rating scales,NRL)评分变化、镇痛有效率及不良反应。结果:两组患者均取得良好的镇痛疗效,用药7 d后中度以上镇痛有效率,氨酚羟考酮组为100%,曲马多组为95.7%,两组镇痛有效率比较差异无显著性(P>0.05);用药期间个别患者出现头晕、嗜睡和恶心、呕吐,未发生明显的呼吸抑制及精神依赖性。结论:氨酚羟考酮片用于治疗腰腿痛疗效确切,不良反应小。

Objective： To observe the analgesic effect of oxycodone-acetaminophen tablet in the treatment of baekleg pain in comparison with the effect of Tramadol. Methods ： One hundred adult patients with moderate-tosevere backleg pain were divided into oxycodone-aeetaminophen tablet（n = 54） and Tramadol （n =46） groups by random number table method. Patients orally took one tablet of either oxyeodone-aeetaminophen tablet or Tramadol. The numeric rating scales （NRS） , numeric changes, efficacy rate of relieving pain and the adverse reactions were observed before and after the treatments. Results ： Both effects of oxycodone-acetaminophen tablet and Tramadol on pain treatment were good. The pain relief rates were 100% and 95.7% , respectively, after treatment with oxycodone-acetaminophen tablet and Tramadol. The difference in pain relief rates was not significant in the two groups. Adverse reactions, including dizziness, lethargy, nausea and vomiting, occurred in a few patients, but no obvious respiratory depression and psychological dependence occurred. Conclusion： oxycodone-acetaminophen tablet has definite effect and slight adverse reaction in pain treatment.