氨酚羟考酮治疗带状疱疹后遗神经痛的疗效

Efficacy of oxycodone-acetamainophen on postherpetic neuralgia in patients with zoster

目的:观察氨酚羟考酮与双氯芬酸钠治疗带状疱疹后遗神经痛的疗效。方法:120例患者随机分成试验组和对照组,均给予维生素等常规治疗,试验组服用氨酚羟考酮,对照组服用双氯芬酸钠,分别于治疗结束及1月后进行疗效对比,于治疗前、治疗3,7,14,30 d观察疼痛视觉模拟评分(VAS)变化。结果:治疗结束及1月后试验组痊愈率及有效率明显高于对照组。试验组治疗后与治疗前VAS评分比较有显著性差异,对照组治疗前后比较差异无显著性。结论:试验组临床疗效明显优于对照组,VAS评分明显下降。

Objective： To observe the efficacy of oxycodone-acetamainophen on postherpetic neuralgia in patients with zoster as compared with diclofenac sodium. Methods： In an open randomized study, 120 patients were treated with oral tablets of oxycodone-acetamainophen or dual release enteric-coated capsules of diclofenac sodium. The efficacies were compared 1 month after the treatments, the transformation of VAS was observed 3, 7, 14 and 30 days after the treatments. Results： The cure rate and response rate at the end of, or 1 month after, the treatments were higher in oxycodone-acetamainophen group than in diclofenac sodium group. The VAS was significantly reduced after treatment with oxycodone-acetamainophen, but was not significantly changed after treatment with dielofenae sodium. Conclusion： The efficacy （VAS decline） of oxycodone-acetamainophen is notably better than that of diclofenac sodium.