沙利度胺联合干扰素α-2b治疗原发性骨髓纤维化疗效观察

Therapeutic Effect of Thalidomide Combined With Interferon-α-2b for Treatment of Idiopathic Myelofibrosis

目的:观察沙利度胺联合干扰素α-2b治疗原发性骨髓纤维化(IMF)的疗效。方法:IMF患者9例,口服沙利度胺100～250mg/d,分2～3次口服。干扰素α-2b300万U/次,皮下注射,3次/周,治疗3个月以上。根据治疗前后白细胞计数、血红蛋白测定、血小板计数、脾脏大小的变化、腹胀的改善及骨髓活检来评定疗效。结果:9例脾肿大患者均明显缩小,其中4例巨脾患者缩小更显著;5例白细胞升高患者,3例恢复正常,2例明显降低;4例轻中度贫血患者2例恢复正常,2例有所上升;3例血小板升高患者,均恢复正常;6例腹胀患者,4例消失,2例明显减轻;复查骨髓活检(髂后),9例IMF患者治疗前后骨髓纤维化无明显进展。结论:沙利度胺联合干扰素α-2b是治疗IMF的有效方法之一。

Objective： To observe the therapeutic effect of thalidomide combined with interfero-α-2b for treatment of idiopathic myelofibrosis （IMF）. Methods： Nine patients with IMF were enrolled into the study. All the patients received thalidomide 100-250 mg/d orally and interferon-α-2b 3 million units hypodermicly 3 times a week for more than 3 months. Therapeutic effect was evaluated by leucocyte count, hemoglobin determination, blood platelet count, the size of spleen, the relief of abdominal distention and bone marrow biopsy before and after treatment. Results： The size of spleen was smaller obviously in 9 patients, and more prominent in 4 cases with huge spleen. Among 5 cases with high leucocytie count, 3 cases recovered, 2 cases decreased obviously. Among 4 cases with ane mia, 2 cases recovered, 2 cases improved. All 5 cases with high blood platelet count recovered. Among 6 cases of abdominal distention, 4 cases disappeared, 2 cases improved obviously. There was no obviously aggravation of myelofibrosis before and after treatment in 9 cases with IMF. Conclusions： Thalidomide combined with interferon-α-2b is one of the effective methods for treatment of idiopathic myelofibrosis.