感染中毒症患者血清神经元特异性烯醇化酶的变化

Changes of Neuron-specific Enolase in Patients With Sepsis

目的:探讨感染中毒症患者血清神经元特异性烯醇化酶(NSE)的变化及意义。方法:用双抗体夹心法测定52例感染中毒症患者血清NSE浓度。结果:感染中毒症组血清NSE浓度显著高于对照组(P<0.05);严重感染中毒症和感染中毒症休克组血清NSE浓度显著高于普通感染中毒症组(P<0.01),普通感染中毒症组血清NSE浓度与对照组相比差异无统计学意义(P=0.055)。结论:血清NSE浓度升高可作为提示感染中毒症患者神经元细胞受损的辅助性指标,也是判断病情预后的指标之一。

Objective： To explore the changes of neuron-specific enolase （NSE） in patients with sepsis and its significance. Methods： Levels of NSE in 52 patients with sepsis were detected by the method of double antibody sandwich. Results： Levels of NSE was significantly higher in sepsis group than those of the control group （P〈0.05）. Levels of NSE were significantly higher in severe sepsis and septic shock group than those of the ordinary sepsis group （P〈0.0l）. There was no significant difference in level of NSE between the ordinary sepsis group and the control group （P = 0. 055）. Conclusions： NSE can be used to detect damage of nerve cell in patients with sepsis and may be regarded as one of the indicators in predicting the prognosis.