淋巴样增强因子1在尖锐湿疣皮损及其癌变组织中的表达

Expression of lymphoid enhancing factor -1 in condyloma acuminatum

目的:研究淋巴样增强因子1在高危型人乳头瘤病毒(HPV)16/18感染所致的尖锐湿疣及其癌变组织中的表达,探讨Wnt信号通路在尖锐湿疣癌变中的作用。方法:对经HPV分型PCR检测试剂盒检测HPV16/18型阳性的35例尖锐湿疣组织和6例尖锐湿疣癌变组织,应用免疫组化方法检测淋巴样增强因子1在尖锐湿疣皮损及其癌变组织中的表达水平。结果:尖锐湿疣患者皮损及其癌变组织中淋巴样增强因子1表达水平均显著高于正常对照组。结论:Wnt信号通路的激活在尖锐湿疣癌变发生机制中可能起着十分重要的作用。

Objective： To investigate the expression of lymphoid enhancing factor （LEF-1） in condyloma acuminatum （CA） and the carcinogenesis. Methods： The immunohistochemistry was used to detect the expression of LEF-1 in the skin lesion of CA and the carcinomatous tissue of CA. Results： The skin lesions of 35 cases of condyloma acuminatum and the carcinomatous tissues of 6 cases of CA were studied. The expression levels of lymphoid enhancing factor 1 in the specimens of skin lesions and carcinomatous tissues of CA were significantly higher than those of normal control. Conclusion： The activation of Wnt signaling may play an important role in the carcinogenesis of CA.