治疗糖尿病高频中药的降血糖作用研究

Studies on Hypoglycemic Effect of High Frequency Chinese Medicines for Diabetes

目的研究治疗糖尿病高频中药的降血糖作用。方法收集和统计出治疗糖尿病的前二十味高频中药和它们的平均处方量,用四氧嘧啶致糖尿病大、小鼠模型观察它们的降血糖效果,剂量相关性及有无相互协同作用。结果二十味高频中药中黄连、五味子、葛根、黄芪对四氧嘧啶致糖尿病小鼠模型的降血糖作用较显著,葛根、黄芪的降血糖作用在临床常用剂量附近没有剂量相关性,对四氧嘧啶致糖尿病大鼠的降血糖无相互协同作用,但对升高模型动物的血清胰岛素、降低尿微量白蛋白和肾脏系数则各有特色。结论治疗糖尿病高频中药中黄连、五味子、葛根、黄芪的降血糖效果较好。

OBJECTIVE To study on hypoglycemic effects of high frequency Chinese medicines （HFCMs） for diabetes. METHODS Twenty HFCMs for diabetes and their average dosage were collected by statistics. Their hypoglycemic effects, synergistic effects and dosage associations were observed on rat and mouse diabetic models induced by alloxan monohydrate. RESULTS Rhizoma Coptidis, Fructus Schisandrae,Radix Astragali, Radix Puerariae were more effective to lower the serum glucose levels of diabetic mouse models induced by alloxan monohydrate. There was no dosage association observed near the clinical dosage for Radix Astragali, Radix Puerariae. No synergistic effects to lower the serum glucose levels of diabetic rat model between Rhizoma Coptidis ,Radix Astragali and Radix Puerariae were observed. CONCLUSION In the most frequently prescribed traditional Chinese medicines for diabetes, Rhizoma Coptidis, Fructus Schisandrae ,Radix Astragali and Radix Puerariae are more effective to lower the serum glucose levels.