摘要
目的探讨盐酸戊乙奎醚(PH)对体外循环肺损伤的保护作用。方法选取24例体外循环下心脏手术患者,随机分成两组,每组12例:盐酸戊乙奎醚组(P组),在麻醉开始前和体外循环开始前经静脉给盐酸戊乙奎醚各一次,剂量均为0.02mg/kg;常规对照组(C组)在相应给药时间予等体积生理盐水静脉注射。在围术期不同时间点检测肺动态顺应性和氧合指数,评估肺功能的变化;同时检测血肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)。结果两组患者术后肺顺应性及氧合指数均较术前低(P〈0.05);P组术中和术后多个时间点的肺顺应性及氧合指数明显高于对照组(P〈0.05)。所有患者血TNF—α、IL-6、IL-8均较术前明显升高(P〈0.05),但P组明显低于对照组(P〈0.05)。结论盐酸戊乙奎醚对体外循环肺损伤有一定的保护作用。
Objective To study the protection effect of penehyclidine hydrochloride on cardiopulmonary bypass induced lung injury. Methods Twenty - four patients suffered congenital heart disease and prepared to receive operation with cardiopulmonary bypass were divided randomly into two groups as: penehyclidine hydrochloride group (group P) and control group (group C), 12 patients in each group. The patients in group P received intravenous penehyclidine hydrochloride 0. 02 mg/kg at the beginning of induction of anesthesia and the beginning of cardiopulmonary bypass, and the patients in group C received equal volume saline respectively. At different point of per/operative period, dynamic compliance of lung and oxygenation index were detected to evaluate the change of pulmonary function, and the blood TNF - α, IL -6, IL -8 levels were detected. Results Dynamic compliance of lung and oxygenation index decreased after cardiopulmonary bypass in both two groups ( P 〈0. 05 ). In the group P, Dynamic compli- ance of lung and oxygenation index were significantly higher than that in the control group after cardiopulmonary bypass ( P 〈 0. 05 ). The levels of blood TNF - α, IL - 6, IL - 8 increased after eardiopulmonary bypass in both two groups ( P 〈 0.05 ). The levels of blood TNF - α, IL - 6, IL - 8 in group P were higher than that in the control group respectively ( P 〈 0. 05 ). Conclusions Penehyclidine hydrochloride showed protection effect of cardiopulmonary bypass induced lung injury in this study.
出处
《中国实用医刊》
2009年第9期27-29,共3页
Chinese Journal of Practical Medicine
关键词
盐酸戊乙奎醚
体外循环
肺损伤
保护作用
Penehyclidine hydrochloride
Cardiopulmonary bypass
Lung injury
Protection effect