脂联素的病理生理学研究进展

The Progress in Research on the Physiological and Pathophysiological Role of Adiponectin

脂联素是一种特异的脂肪因子,主要由脂肪细胞分泌,在脂肪组织中大量表达。它有两种受体,脂联素受体1和脂联素受体2,它们能与脂联素结合发挥抵抗糖尿病的作用。因此,脂联素及其受体是与胰岛素抵抗相关的肥胖性疾病的治疗靶点。本文概述了脂联素及其受体的特征,机体内脂联素水平的多种调控因素,以及脂联素在胰岛素抵抗、糖尿病及其它代谢疾病过程中的作用机制。

Adiponectin is an adipokine that is expressed specifically and abundantly in adipose tissue. The adiponectin receptors, AdipoR1 and AdipoR2, which mediate the antidiabetic metabolic actions of adiponectin. Adiponectin and adiponectin receptors represent potential versatile therapeutic targets to combat obesity-linked diseases characterized by insulin resistance. This review describes the characteristics, molecular mechanisms, and several important regulating factors of adiponectin and adiponectin receptors in insulin resistance, diabetes, and other metabolism diseases.