经典Wnt信号通路中β-连环蛋白的影响因素

Influential Factors of β-catenin in the Classic Wnt/β-catenin Signaling Pathway

Wnt/β-连环蛋白信号途径在动物生长发育过程中发挥了重要作用。一旦该通路中相关信号传递发生异常改变,就可能导致该通路异常活化,从而影响生物的胚胎发育、能量代谢等一系列生理过程,甚至会导致肿瘤的发生及恶化。而这一异常变化的中心事件则是细胞内β-连环蛋白丰度、分布以及功能的变化。现从β-连环蛋白的影响因素这一角度阐述了经典Wnt通路的改变,进而加强对该通路异常和肿瘤的关系的了解。

Wnt/β-catenin signaling pathway plays an important role in the processes of growth and development of vertebrates. The abnormal activation of the pathway could result from the abnormal change or expression of relevant moleculars, which affects a series of physiological processes, such as the embryonic development and energy metabolism, and even leads to tumorigenesis. However, the alterations of content, distribution and function of β-catenin are the mark of the abnormalities of Wnt pathway. This paper expounds the influential factors of β-catenin, which should enhance the understanding of the relationship between the pathway and the tumor.