湿热痹煎剂治疗类风湿关节炎(湿热痹阻型)临床观察

Clinical Observation of Shirebi Decoction for the Treatment of Rheumatoid Arthritis with Damp-heat Blockage Syndrome

目的:观察湿热痹煎剂治疗类风湿关节炎(湿热痹阻型)的临床疗效。方法:将100例患者随机分为2组,对照组50例采用甲氨蝶呤治疗,治疗组50例采用湿热痹煎剂治疗。2组疗程均为12周,观察2组治疗前后中医临床症状、体征、血清学指标变化情况。结果:2组症状体征总积分治疗前后比较,差异有非常显著性意义(P<0.01);2组症状体征总积分治疗后比较,差异有显著性意义(P<0.05)。2组总体疗效比较,差异有显著性意义(P<0.05)。2组治疗前后红细胞沉降率(ESR)、C-反应蛋白(CRP)、类风湿因子(RF)、血小板(BPC)、补体C_3、免疫球蛋白(IgG)、晨僵时间、手平均握力比较,差异有显著性或非常显著性意义(P<0.05, P<0.01);2组除晨僵时间外,各项指标比较,差异有显著性或非常显著性意义(P<0.05,P<0.01)。结论:湿热痹煎剂治疗类风湿关节炎(湿热痹阻型)有较好的疗效。

Objective:To observe the therapeutic effect of Shirebi Decoction(SD)for the treatment of rheumatoid arthritis(RA)with damp-heat blockage syndrome.Methods:One hundred qualified patients were equally randomized into 2 groups:the control group received oral use of methotrexate,and the treatment group received oral use of Shirebi Decoction.The treatment lasted 12 weeks.The changes of symptoms and signs as well as the serological indexes before and after treatment were observed.Results:The total score of symptoms and signs were improved in the two groups after treatment(P<0.01 compared with that before treatment),and the improvement was obvious in the treatment group(P<0.05 compared with that in the control group).The difference of total effective rate was significant between the two groups(P<0.05).The serological indexes such as erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),rheumatoid factor (RF),BPC,compliment C3,and IgG,morning stiffness time and average hand grip strength were improved in the two grroups after treatment(P<0.05 or P<0.01 compared with those before treatment), and the improvement of above indexes except morning stiffness time was obvious in the treatment group(P<0.05 or P<0.01 compared with that in the control group).Conclusion: Shirebi Decoction exerts certain effect for the treatment of rheumatoid arthritis with damp-heat blockage syndrome.