脂联素和内脂素与胎儿生长发育的关系

Relationship of adiponectin and visfatin with fetus intrauterine growth

目的探讨脂肪因子——脂联素和内脂素与胎儿生长发育的关系。方法收集2007年6月至12月北京军区总医院妇产科住院分娩的产妇42例，其中分娩胎儿生长受限（FGR）儿14例（FGR组），分娩巨大儿14例（巨大儿组），分娩出生体重正常新生儿14例（对照组）。采用酶联免疫吸附试验（ELISA，双抗体夹心法）检测3组产妇血和新生儿脐血中的脂联素和内脂素的水平，并分析新生儿脐血中脂联素和内脂素水平与产妇血中水平的相关性。结果（1）FGR组产妇血中内脂素水平为（41．4±5．5）μg/L，明显高于对照组的（34．7±4．9）μg/L和巨大儿组的（37．3±4．4）μg/L，分别比较，差异均有统计学意义（P〈0．01，P〈0．05）；巨大儿组产妇血中脂联素水平为（4．1±1．3）mg／L，显著低于对照组的（6．6±1．5）mg／L和FGR组的（6．4±1．3）mg／L，分别比较，差异均有统计学意义（P均〈0．01）。（2）FGR组新生儿脐血中内脂素水平为（58．1±7．6）μg／L，明显高于对照组的（42．6±7．8）μg/L和巨大儿组的（48．5±9．1）μg/L，分别比较，差异均有统计学意义（P〈0．01，P〈0．05）；巨大儿组新生儿脐血中脂联素水平为（6．5±1．3）mg／L，低于对照组的（7．7±1．5）mg／L和FGR组的（7．7±1．0）mg／L，分别比较，差异均有统计学意义（P均〈0．05）。（3）脐血中内脂素水平高于产妇血中的水平，两者呈显著正相关关系（r=0．720，P〈0．01）；脐血中脂联素水平略高于产妇血中的水平，两者无明显相关性（r=0．301，P〉0．05）。结论内脂素水平的升高可能与FGR的发生有关，脂联素水平的降低可能与巨大儿的发生有关。

Objective To explore the correlation between adipocyte factors （adiponectin and visfatin） and fetus intrauterine growth. Methods Enzyme immunoassay was used to measure the adiponectin and visfatin levels in maternal and umbilical serum from 14 women with fetal growth restriction （FGR group）, 14 women with macrosomia （macrosomia group） and 14 normal pregnant women （control group）. The correlations of cord serum adiponectin and visfatin with maternal serum adiponectin and visfatin were analyzed. Results （ 1 ） Serum visfatin levels in FGR mothers [ （ 41.4 ± 5.5 ） μg/L were significantly higher than that in control women [ （34. 7 ±4. 9） μg/L] and macrosomia mothers [ （37. 3 ±4.4） μg/L; P 〈 0. 01, P 〈 0. 051. Serum adiponectin levels in macrosomia mothers [ （4. 1 ±1.3） μg/l,] were significantly lower than that in control women [ （6. 6 ±1.5） mg/L] and FGR mothers [ （6.4 ±1.3） rag/L; P 〈0. 01 ]. （2） Serum visfatinln levels in FGR babies [ （58.1 ±7.6） μg/L]were significantly increased than that in control newborns [ （42.6 ± 7.8） μg/L] and macrosomia babies [ （48.5 ± 9. 1 ） μ/L; P 〈 0. 01, P 〈0. 051. Serum adiponectin levels in macrosomia babies[ （6. 5 ± 1.3）mg/L] were significantly decreased than that in control newborns [ （7.7 ± 1.5） mg/I.] and FGR babies [ （7.7 ± 1.0） mg/L; P 〈 0. 05, P 〈 0. 05 ]. （3） Maternal serum visfatin levels were positively correlated with umbilical serum visfatin levels （ r = 0. 720, P 〈 0. 01 ）. Umbilical serum adiponectin levels were higher than that in maternal serum, but there were no relationship between them （ r = 0. 301, P 〉 0. 05）. Conclusion The changes of visfatin and adiponectin levels may be related to the occurrence of FGR and fetal macrosomia.