血清DNA定量及基因甲基化状态检测在卵巢上皮性癌诊断中的应用
摘要
卵巢恶性肿瘤是病死率最高的女性生殖系统肿瘤，其中90％为卵巢上皮性癌（卵巢癌），而70％的患者诊断时已达Ⅲ期或Ⅳ期，5年生存率仅为15％-20％。因此发现新的既敏感又特异的肿瘤标志物，对卵巢癌的早期诊断、提高生存率具有重要意义。近年的研究发现，作为表观遗传的主要方式之一，DNA异常甲基化是肿瘤发生的早期事件，可早于基因及其表达产物的改变。而且，肿瘤患者血清DNA含量明显升高，虽然其来源尚未十分明确，但其具有与肿瘤DNA类似的遗传学和表观遗传学改变。因此，血清DNA的异常甲基化用于肿瘤的早期诊断具有明显的优势和极大的潜力。本研究通过定量检测卵巢癌患者血清DNA含量，
出处
《中华妇产科杂志》
CAS
CSCD
北大核心
2009年第4期295-297,共3页
Chinese Journal of Obstetrics and Gynecology
基金
国家自然科学基金（30571952）
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