脂肪乳作为溶剂行胰腺区域性动脉灌注化疗的临床应用

Regional arterial infusion chemotherapy with lipid emulsion as a solvent for the treatment of advanced pancreatic cancer: a preliminary clinical study

目的探讨以脂肪乳作为溶剂,行胰腺癌区域性动脉灌注化疗治疗中晚期胰腺癌的疗效。方法6例中晚期胰腺癌选择性动脉插管于胰腺癌的供血动脉,灌注吉西他滨、20%脂肪乳混合液。观察疗效、临床受益反应、患者的生存期及不良反应等。结果6例均获临床受益,2例均获临床缓解,Kaplan-Meier法计算6、9和12个月的分别生存6例、5例和4例。结论以脂肪乳作为溶剂,行胰腺癌区域性动脉灌注化疗治疗中晚期胰腺癌,可获得较好的临床疗效,患者耐受良好,值得进一步研究。

Objective To investigate the clinical effect of regional intra-arterial infusion chemotherapy with lipid emulsion （LE） as the solvent for the treatment of advanced pancreatic cancer. Methods Selected catheterization of tumor-feeding artery was performed in 6 patients with advanced pancreatic cancer, and a mixture （gemcitabine in 20% LE） was infused via the catheter. The tumor response and the clinical results were observed. Results The tumor response rate was 33.3%, while the clinical benefit from the treatment was 100%. Using Kaplan-Meier calculus, the survival rate of 6, 9 and 12 months was 100%, 83.3% and 66.7%, respectively. Conclusion For the treatment of advanced pancreatic cancer, regional intra-arterial infusion with gemcitabine-LE mixture can be well tolerated by the patients with good clinical results.