外周动脉支架聚丙交酯乙交酯涂层的制备及其性能研究

PLGA-coating preparation of peripheral arterial stents and its properties

目的制备外周动脉镍钛合金支架聚丙交酯乙交酯复合物(PLGA)涂层,对其性能进行实验研究。方法利用浸涂法将PLGA涂敷于镍钛记忆合金外周动脉支架表面,用体式显微镜、原子力显微镜、电子扫描显微镜对涂层进行表面形貌、机械性能、血液相容性、降解行为等实验研究。结果PLGA可在镍钛合金支架表面形成光滑涂层,经过一定机械作用涂层仍能很好地与支架表面结合;PLGA涂层与裸镍钛合金表面相比,有更少的血小板黏附;PLGA涂层降解速度较平稳,基本符合线性降解规律,完全降解约需6周。结论PLGA涂层与镍钛合金支架可形成良好表面形态及稳定结合力,血液相容性好,降解速度适中,在预防支架植入后再狭窄方面将会发挥积极作用。

Objective To make the coating with polylactide coglycotide （PLGA） for the peripheral arterial stents and to study the biological properties of the coating. Methods By using dip-covering technique the Ni-Ti alloy stent was coated with PLGA. The surface morphology, physical features, blood compatibility and degradation of the coating were observed and tested with the help of stereomicroscope and electro-scanning microscope. Results PLGA could form a smooth coating layer on the stent surface, the coating layer kept tight cohesion with the stent even after it was repeatedly beuded. Compared with naked Ni- Ti alloy stent, there was less platelet adhesion on PLGA-coating stent. The degradation rate of the PLGA coating was rather steady, which followed the linear rule, and the complete degrading time was about 6 weeks. Conclusion PLGA coating possess ideal surface morphology, stable bond to the stent, fine compatibility with blood and moderate degradation rate, thus, it might be of value in preventing the restenosis after stent implantation.