灌肠治疗G6PD缺陷新生儿高胆红素血症的疗效

Enema Therapy in G6PD Deficient Neonates with Hyper-bilirubinemia

目的探讨灌肠治疗葡萄糖-6-磷酸脱氢酶(G6PD)缺陷新生儿高胆红素血症的疗效。方法将82例G6PD缺陷新生儿高胆红素血症患儿随机分成二组,二组均采用综合治疗,治疗组42例用开塞露加生理盐水灌肠,每天1次,共5天,对照组无灌肠,观察记录二组新生儿每日TB值、光疗天数和胎粪排清时间。结果治疗组光疗天数和胎粪排清时间均比对照组缩短(P<0.05)。结论灌肠对G6PD缺陷新生儿高胆红素血症有治疗作用,能缩短光疗天数及胎粪排清时间。

Objective To explore the clinical effects of enema therapy in G6PD deficient neonates with hyper - bilirubinemia. Methods Total 82 G6PD deficient neonates with hyper - bilirubinemia treated with routine therapy were randomly divided into 2 groups, treatment group （ 42 patients） was given enema with mixed kaiselu and normal saline once a day for 5 days. Daily TB indexes, duration of phototherapy and time of meconium exhaustion were recorded. Results Duration of phototherapy and time of meconium exhaustion were significantly shortened in treatment group compared with those in control group （ P 〈 0.05）. Conclusion Enema has therapeutic effect in G6PD deficient neonates with hyper - bilirubinemia. It can shorten duration of phototherapy and time of meconium exhaustion .