新活素治疗中重度肺动脉高压疗效观察

Effect of Intravenous rhBNP on Pulmonary Artery Hypertention

目的观察中重度肺动脉高压患者静脉应用新活素(重组人脑钠肽)的临床疗效。方法46例中重度肺动脉高压患者,常规治疗基础上静脉应用新活素组作为治疗组,其余作为对照组;观察并比较两组治疗前后肺动脉压力、6min步行试验、动脉血氧分压的变化。结果观察两周后,治疗组在肺动脉压力、6min步行距离、动脉血氧分压方面均明显改善,较对照组有统计学差异(P<0.05);治疗前后,对照组在肺动脉压力、动脉血氧分压无明显改善;但6min步行距离提高,有统计学差异。结论新活素可用于中重度肺动脉高压的治疗,快速有效,且不良反应少。

Objective To observe effect of intravenous rhBNP on moderate and severe pulmonary artery hypertention（PAH）. Methods Total 46 patients with moderate to severe PAH ,which were divided into 2 groups ： control group ,22 eases,received routine treatment, treatment group, 24 cases , received rhBNP besides routine treatment. Patients were evaluated and compared for pulmonary arterial pressure, 6 -minute walking text, artery partial pressure of oxygen. Results At 2 weeks in comparison of two groups, there was significant diffreret in pulmonary arterial pressure,6 -minute walking distance, artery partial pressure of oxygen （ P 〈 0.05 ）. The 6 - minute walking distance increased in the control group. Conclusion Combined with the standard treatment, rhBNP can be used in moderate and severe pulmonary artery hypertcntion treatment, quickly and efficiently, and adverse reactions small.