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造血干细胞基因转染研究进展 被引量:3

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摘要 原始的造血干细胞由于其全能性,能再生整个造血系统和免疫系统,是基因治疗的理想靶细胞。目前对其转基因的研究已取得较大发展,转染率明显提高。本文主要从腺病毒转染、逆转录病毒和慢病毒转染、转座子和人工染色体转染,以及目前的转染缺陷等方面进行综述,提出构建一个类型序列特异性的造血干细胞基因载体仍是长期目标。
出处 《国际检验医学杂志》 CAS 2009年第4期355-357,共3页 International Journal of Laboratory Medicine
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  • 1Mei YF, Segerman A, Lindman K, et al. Human hematopoietic (CD34+) stem cells possess high affinity receptors for adenovirus type 11p[J].Virology,2004,328(2):198-207.
  • 2Wang H, Cao H, Wohlfahrt M, et al. Tightly regulated gene expression in human hematopoietic stem cells after transduction with helper dependent Ad5/35 vectors[J]. Exp Hematol,2008,36 (7) :823-831.
  • 3Lu ZZ,Ni F, Hu ZB,et al. Efficient gene transfer into hematopoietic cells by a retargeting adenoviral vector system with a chimeric fiber of adenovirus serotype 5 and 11p[J].Exp Hematol, 2006,34 (9):1170-1182.
  • 4Schroers R, Hildebrandt Y, Hasenkamp J, et al. Gene transfer into human T lymphocytes and natural killer cells by Ad5/F35 chimeric adenoviral vectors[J].Exp Hematol,2004,32(6):536-546.
  • 5Kelly PF, Radtke S, von Kalle C, et al. Stem cell collection and gene transfer in Fanconi anemia[J]. Mol Ther, 2007,15 ( 1 ) : 211- 219.
  • 6Hall KM, Horvath TL, Abonour R, et al. Decreased homing of retrovirally transduced human bone marrow CD34+ cells in the NOD/SCID mouse model[J]. Exp Hematol, 2006, 34 (4) : 433-442.
  • 7Crcareva A,Saito T,Kunisato A,et al. Hematopoietic stem cells expanded by fibroblast growth factor-1 are excellent targets for retrovirus-mediated gene delivery[J]. Exp Hematol, 2005, 33 (12) : 1459-1469.
  • 8Santoni de Sio F, Naldini L. Short-term culture of human CD34 + cells for lentiviral gene transfer[J].Methods Mol Biol, 2009,506 : 59-70.
  • 9Relander T,Johansson M,Olsson K,et al. Gene transfer to repop ulating human CD34+ cells using amphotropic, GALV -, or RD114-pseudotyped HIV1 based vectors from stable producer cells[J].Mol Ther,2005,11(3) :452 -459.
  • 10Li Z, Modlich U, Baum C. Safety and efficacy in retrovirally modified haematopoietic cell therapy[J]. Best Pract Res Clin Haematol,2004,17(3) :493-503.

同被引文献31

  • 1陈奎,秦书俭.siRNA沉默HLA-A2基因表达对人脐带间充质干细胞诱导成骨的影响[J].解剖科学进展,2010,16(5):413-417. 被引量:2
  • 2邓洪新,田聆,魏于全.基因治疗的发展现状、问题和展望[J].生命科学,2005,17(3):196-199. 被引量:35
  • 3汪赤宇,谢毅.脐血造血祖细胞培养及T淋巴细胞亚群的研究[J].中华血液学杂志,1994,15(4):178-180. 被引量:12
  • 4Lane TA.Umbilical cord blood grafts for hematopoietic transplantation in adults:a cup half empty or half full[J].Transfusion,2005,45 (6):1027-1034.
  • 5Laughlin MJ,Barker J,Bambach B,et al.Hematopoietic engraftment and survival in adult recipients of umbilical cord blood from unrelated donors[J].N Engl J Med,2001,344 (24):1815-1822.
  • 6Brunstein CG,W agner JE.Umbilicial cord blood transplantation and banking.A nnu Rev Med,2006,57(3):403-417.
  • 7Nauta AJ,Kruisselbrink AB,Lurvink E,et al.Enhanced engraftment of umbilical cord blood-derived stem cells in NOD/SCID mice by co -transplantation of a second unrelated cord blood unit[J].Exp Hematol,2005,33 (10):1249-1256.
  • 8Lima MD,John LSS,Wieder ED,et al.Double-chimaerism after transplantation of two human leucocyte antigen mismatched,unrelated cord blood units[J].Br J Haematol,2002,119(3):773-776.
  • 9Ooi J,Iseki T,Takahashi S,et al.Unrelated cord b1ood transplantation for adult patients with denovo acute myeloid leukemia[J].Blood,2004,103(2):489-491.
  • 10Mello CC,Conte DJ.Revealing the world of RNA interference[J].Nature,2004,431(7006):338.

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