乳腺癌组织VEGF-C表达临床意义的研究

Clinical significance of vascular endothelial growth factor C expression in breast carcinoma

目的:观察乳腺癌组织血管内皮生长因子-C(VEGF-C)的表达与淋巴结转移的相关性,明确VEGF-C能否作为乳腺癌淋巴结转移的标志。方法:采用免疫组织化学SP法对108例乳腺癌组织切片染色,观察VEGF-C的表达情况,评价VEGF-C的表达与淋巴结转移及其他临床病理因素的关系。结果:77例(71.3%)乳腺癌组织VEGF-C呈阳性表达,VEGF-C阳性表达与淋巴结转移有明显关系(χ2=6.245,P=0.044),同时与肿瘤大小亦有相关性,χ2=6.708,P=0.035。VEGF-C的表达与患者年龄、病理类型以及ER、PR、c-erbB-2的表达情况无明显相关。结论:VEGF-C对于乳腺癌淋巴结转移起重要作用,是乳腺癌重要的预后因子,而且与肿瘤大小呈正相关。

OBJECTIVE： To determine the feasibiligy of vas cular endothelial growth faetor-C （VEGF-C） could be as a tumor marker by detecting the relationship between VEGFC expression and lymph node status in breast cancer. METHODS： VEGF-C expression was assessed by immunohistochemistry in 108 cases of breast carcinomas. The relationship between expression of VEGF-C and lymph node status and clinicopathological features in breast cancer was analyzed. RESULTS： VEGF-C expression was i dentified in 77 cases （71.3 %）. Positive VEGF-C was significantly correlated with lymph node metastasis （χ^2= 6. 245,P=0. 044） and tumor size （χ^2=6. 708, P=0. 035）. There was no significant correlation between VEGF-C expression and the age of the patients, or hormone receptor status, or c erbB2 status. CONCLUSIONS： VEGF-C plays a crucial role in lymph node metastasis and may be a significant prognostic factor for long term survival in breast canc er. VEGF C also has positive association with tumor size.