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内毒素和细胞因子在酒精性肝病中的作用 被引量:1

Functions of Lipopolysaccharide and Cytokines in Alcoholic Liver Disease
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摘要 酒精性肝病发病机制比较复杂,其中内毒素、细胞因子导致的肝细胞凋亡发挥了关键作用。酒精致肠道粘膜通透性增加,引起高内毒素血症,内毒素作用于kupffer细胞产生过量细胞因子如肿瘤坏死因子a(TNF-a)等,TNF-a与肝细胞表面的相应受体结合,诱导肝细胞凋亡,引起肝细胞损害。 The pathogenesis of alcoholic liver disease has been demonstrated to be very complex. It has been recorded that endotoxin and cytokines play a key role in causing liver cell apoptosis. Alcohol could increase the permeability of intestinal mucosa and thus cause high endotoxemia. The endotoxin in kupffer cells produce excessive cytokines such as tumor necrosis factor (TNF alpha), which are bound with the corresponding receptor on liver cell surface, inducing liver cells apoptosis and causing liver cell damage.
作者 樊耀敏 薛挥
出处 《现代生物医学进展》 CAS 2009年第8期1570-1572,共3页 Progress in Modern Biomedicine
关键词 内毒素 KUPFFER细胞 NF—κB 细胞因子 肝细胞凋亡 Lipopolysaccharide Kupffer cell NF-κB Liver cell apoptosis
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