期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

肿瘤MDR1基因表观遗传调控及其对宫颈癌的启示 被引量：1

Epigenetic Regulation of Multidrug Resistance Gene 1 and its Effect on Cervical Cancer
原文传递
导出
摘要 多药耐药是肿瘤细胞化疗失败的重要原因,多药耐药基因1过度表达P-gP是产生耐药的主要机制,表观遗传通过对DNA的甲基化和组蛋白脱乙酰化的修饰来调节MDR1基因的转录。应用化学物质可以逆转MDR1基因的过度表达,提高化疗敏感性,这将为癌症治疗提供新策略,也为宫颈癌的治疗提供新思路。 The important reason of chemotherapy failure is that multidrug resistance gene MDR1 of cervical cancer tumor cell overexpressed P-glycoprotein, which causing multidrug resistance. The transcription of MDR1 gene can be regulated through the DNA methylation and histone modification. Using chemical factors to intervene in the epigenetic modification can reverse the MDR1 gene overexpression, and improve the sensitivity of chemotherapy. It provides a novel strategy for treatment of cervical cancer as well as other malignant tumors.
作者 高丽敏 王英红
机构地区 石河子大学第一附属医院妇产科
出处 《现代生物医学进展》 CAS 2009年第8期1588-1590,1600,共4页 Progress in Modern Biomedicine
关键词 多药耐药基因1(MDR1) 表观遗传修饰 子宫颈癌 Multidrug resistance （MDR） Epigenetic modification Cervical cancer
分类号 R730.53 [医药卫生—肿瘤]
  • 相关文献

参考文献4

二级参考文献89

  • 1[1]Ogretmen B, Safa AR. Identification and characterization of the MDR1 promoter-enhancing factor 1 (MEF1) in the multidrug resistant HL60/VCR human acute myeloid leukemia cell line. Biochemistry, 2000; 39:194-204
  • 2[2]Jurcic JG, Larson SM, Sgouros G, et al. Targeted alpha particle immunotherapy for myeloid leukemia. Blood, 2002; 100: 1233-1239
  • 3[3]Kusaba H, Nakayarna M, Harada T, et al. Maintenance of hypomethylation status and preferential expression of exogenous human MDR1/PGY1 gene in mouse L cells by YAC mediated transfer. Somat Cell Mol Genet, 1997; 23:259- 274
  • 4[4]Nakayama M, Wada M, Harada T, et al. Hypomethylation status of CpG sites at the promoter region and overexpression of the human MDR1 gene in acute myeloid leukemias. Blood, 1998; 92: 42964307
  • 5[5]Tada Y, Wada M, Kuroiwa K, et al. MDR1 gene overexpression and altered degree of methylation at the promoter region in bladder cancer during chemotherapeutic treatment. Clin Cancer res, 2000;6:4618-4627
  • 6[6]Toyota M, Kopecky KJ, Toyota MO, et al. Methylation profiling in acute myeloid leukemia. Blood, 2001; 97:2823- 2829
  • 7[7]Garcia-Manero G, Bueso-Ramos C, Daniel J, et al. DNA methylation patterns at relapse in adult acute lymphocytic leukemia. Clin Cancer Res,2002; 8:1897 - 1903
  • 8[8]Fryxell KB, McGee SB, Simoneaux DK, et al. Methylation analysis of the human multidrug resistance 1 gene in normal and leukemic hematopoietic cells. Leukemia, 1999; 13:910-917
  • 9[9]Ando T, Nishimura M, Oka Y. Decitabine (5-Aza-2-deoxycyti dine) decreased DNA methylation and expression of MDRl gene in K562/ADM cells. Leukemia, 2000; 14:1915-1920
  • 10[10]Cornwell MM, Smith DE. SP1 activates the MDR1 promoter through one of two distinct G-rich regions that modulate promoter activity. J Biol Chem, 1993; 268:19505-19511

共引文献100

同被引文献14

  • 1左文丽,张翼,何玉玲,刘国文.1,25-二羟基维生素D_3诱导HL-60细胞向成熟单核细胞的分化[J].中国临床康复,2006,10(29):38-40. 被引量：3
  • 2Baguley BC. Multiple drug resistance mechanisms in cancer [ J ]. Mol Biotechnol,2010,46(3 ) :308 - 316.
  • 3Yang X, Zhang X, Fu ML, et al. Targeting the tumor microenvironment with interferon-13 bridges innate and adaptive immune responses [ J ]. Cancer Ce11,2014,25( 1 ) :37 -48.
  • 4Amoozgar Z, Yeo Y. Recent advances in stealth coating of nanoparticle drug delivery systems [ J ]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2012,4(2) :219 -233.
  • 5Jackson AS, Shrikrishna D, Kelly JL, et al. Vitamin D and skeletal mus- cle strength and endurance in COPD [ J ] Eur Respir J, 2013,41 (2) : 309 -316.
  • 6Yang JH, Kim Y, Lim J, et al. Determination of acute leukemia lineage with new morphologic parameters available in the complete blood cell count [ J ]. Ann Clin Lab Sci, 2014,44 ( 1 ) : 19 - 25.
  • 7Lompardlal SL. Daniela laura papademetrio, marilina mascar6, elida maria del Carmen 61varez, silvia elvira hajosl, human leukemic cell lines synthesize hyaluronan to avoid senescence and resist chemotherapy [ J]. Glycobiology ,2013,23 ( 12 ) : 1463 - 1476.
  • 8Valdez M, Amador TM, Francisco MT. Autoimmune uveitis : a pilot study of vitamin D levels and its supplementation effect [ J ]. Invest Ophthalmol Vis Sci,2014,13 ( 1 ) :55 - 60.
  • 9Tse AK, Zhu GY, Wan CK, et al. 1 alpha, 25-dihydroxyvitamin D3 inhi- bits transcriptional potential of nuclear factor kappa B in breast cancer cells[ J]. Mol Immuno1,2010,47 (9) : 1728 - 1738.
  • 10Sahebari M, Nabavi N, Salehi M. Correlation between serum 25 ( OH ) D values and lupus disease activity [ J ]. Lupus, 2014,23 ( 11 ) : 1164 - 1177.

引证文献1

二级引证文献3

现代生物医学进展
2009年 第8期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部