摘要
Toll样受体(TLR)的发现为研究病原生物的识别和免疫应答的起始开辟了新的视角,然而近期研究发现"非-TLR"受体在该过程尤其在抗真菌免疫中亦起着重要作用。其中研究甚为活跃的是C型凝集素受体(CLR)家族的一些成员,包括甘露糖受体、DC-SIGN、Dectin-1、Dectin-2及胶原凝集素。本文对这些受体在真菌识别、摄取、杀伤及其在宿主免疫反应的诱导和调节中所发挥的作用予以综述。
The identification of the Toll-like receptors （TLRs） has shed new insights on innate microbial recognition and the initiation of immune responses; however, recent evidence indicates that the ＇non-TLR＇ receptors also have a significant role in these processes, particularly in antifungal immunity. One of these ＇non-TLR＇ receptors is C-type lectin-receptor （CLRs）family, including the malmose receptor, DC-SIGN, Dectin-1, Dectin-2 and the collectins. Here, we reviewed the roles of these receptors, describing how they contribute to fungal recognition, uptake and killing and also participate in the induction and/or modulation of the host immune response.
出处
《现代生物医学进展》
CAS
2009年第8期1591-1593,共3页
Progress in Modern Biomedicine
基金
国家自然科学基金项目(30772030
30621063)
中国高技术研究发展计划(2006AA02Z165)
国家重点基础研究发展规划(2006CB910800)
关键词
C型凝集素受体
真菌感染
免疫反应
C- type lectin receptor
Fungal infection
Immune response
