苦参素治疗慢性乙型肝炎的疗效观察

Observation of Efficacy of Oxymatrine on Chronic Hepatitis B

目的观察苦参素治疗慢性乙型肝炎的临床疗效。方法将120例慢性乙型肝炎患者随机分为对照组和治疗组。对照组患者单纯给予常规保肝药物治疗;治疗组在给予常规保肝药物治疗的同时加用苦参素治疗。观察两组患者临床疗效及肝功能、纤维化指标、HBV-M、HBV-DNA定量情况。结果对照组总有效率为66.7%,治疗组为85%,两组比较有显著性差异(P<0.05)。治疗组在改善肝功能、HBV-M、HBV-DNA定量等指标方面优于对照组。结论苦参素能够明显改善和消除患者临床症状,显著降低慢性乙型肝炎转氨酶情况,抑制HBV增殖、抗肝纤维化及调节宿主免疫功能,具有升高白细胞等作用。

Objective To observe the clinical efficacy of oxymatrine on chronic hepatitis B.Methods 120 cases of chronic hepatitis B were randomized into control group and treatment group.In control group,routine therapy was applied simply for liver protection.In treatment group,on the basis of the treatment as control group,oxymatrine was supplemented.It was to observe the clinical efficacy,liver function,fibrosis,HBV-M and HBV-DNA in two groups.Results The total effective rate was 66.7% in control group and was 85% in treatment group,indicating significant difference in comparison（P 〈0.05）. The improvement of treatment group in liver function, HBV - M and HBV - DNA were superior to those in control group. Conclusion Oxymatrine relieves clinical symptoms apparently, reduces significantly aminotransferases in chronic hepatitis B, suppresses HBV proliferation, resists hepatic fibrosis, regulates host immune function and increases leukocytes. Hence, the significant efficiency has been achieved.