2型糖尿病与结直肠癌关系的回顾性分析

Retrospective analysis of the relationship between type 2 diabetes mellitus and colorectal cancer

目的探讨结直肠癌患者中伴发2型糖尿病的比例,比较合并糖尿病的结直肠癌患者与普通结直肠癌患者发生淋巴结或远处转移的比率,了解糖尿病是否为结直肠癌发病的重要危险因素,为做好结直肠癌的一级预防提供思路。方法回顾分析286例住院结直肠癌患者的血糖情况,计算2型糖尿病患病率,分别计算合并糖尿病的结直肠癌患者与普通结直肠癌患者发生淋巴结或远处转移的比率。结果结直肠癌患者中2型糖尿病的患病率为8.04%,标准化患病率为3.97%,与全国糖尿病标准化患病率比较差异有显著性(P<0.01);合并糖尿病的结直肠癌患者淋巴结或其他组织器官转移率为69.6%(16/23),高于无糖尿病的结直肠癌患者(42.2%,111/263)。结论糖尿病与结直肠癌患病存在一定的相关性,糖尿病增加了患结直肠癌的风险性。预示2型糖尿病可能是结直肠癌发生的独立危险因素,加强糖尿病的防治将对预防结直肠癌患病和改善预后有重要的作用。

Objectives To figure out the proportion of type-2 diabetes mellitus（DM） among colorectal cancer（ CRC ） patients. To compare the rate of metastasis to lymph node or other organs between DM patients complicated with CRC and CRC patients without DM. To determine whether DM is the important pathogenetic risk factor for CRC. Methods The plasma glucose of 286 CRC patients was analyzed, and the prevalence of DM was calculated. The rates of metastasis to lymph node or other organs in DM patients complicated with CRC and CRC patients without DM were calculated. Results The standardized prevalence of type-2 DM in CRC patients was 3.97% , greater than that of national diabetes screening（P 〈 0. 05 ）. The rate of metastasis to lymph node or other organs increased in DM patients complicated with CRC than that in CRC patients without DM. Conclusion DM is correlated with the oncogenesis of CRC and increases the risk of developing CRC. DM may be one of the risk factors for CRC.