食管癌放射治疗同步化疗临床疗效观察

Clinical study of efficacy of radiotherapy combined with synchronous chemotherapy in treating esophagus cancer

目的探讨食管癌放射治疗同步化疗的临床疗效和毒副反应。方法将符合入组条件的95例食管癌随机分为放化组（47例）和常规放疗组（48例），放化组外照射同常规放疗组，放射治疗当日及外照射剂量达阱36～40Gy时同时合并化疗，化疗方案：氟尿嘧啶（5-Fu）750mg／d，5d；顺铂（DDP）20mg／d，5d；亚叶酸钙（CF）100mg／d，5d；常规放疗组食管癌常规外照射总量D，60～65Cy／6—7周，每次1．8—2．0Gy，每周5次。均采用6MVX线照射。结果放化组和单放组完全缓解率分别为95．8％和83．4％（X^2=3．88，P〈0．05）。放化组毒副反应高于单放组，但可以耐受。结论放射治疗同步DF方案加CF化疗优于单纯放疗，是治疗中晚期食管癌的一种有效方法。

Objective To study the efficacy and side effect of radiotherapy combined with sychronous chemotherapy in treating esophageal cancer. Methods Ninty-five cases of esophageal cancers were randomly divided into two groups. The conventional radiotherapy group（g8 cases） received routine radiotherapy at dosage of 1.8-2. 0 Gy per day,5 times a week to a total dose of 60-65 Gy in 6-7 weeks. The radiotherapy plus chemotherapy group（47 cases）was treated with radiotherapy as radiotherapy group, and at beginning of radiotherapy and radiation dose to 36-40 Gy, the patients also received chemotherapy with 750 mg/d fluorouracil （5-Fu） for 5 d ; 20 mg/d cisplatin （DDP） for 5 d and 100 mg/d calcium folinate （CF） for 5 d. Resuits The short-term CR ＋ PR of CT ＋ RT group and RT group respectively were 95.8% and 83.4% （ X^2 = 3. 88 ,P 〉0.05）. The rate of side effect in CT ＋ RT group was higher than that in RT group. Conclusions The results showed that the efficacy of radiotherapy combined with chemotherapy in treating advanced esophageal cancer is better than that of radiotherapy alone and can improve the survival rate.