席夫碱及其金属配合物的合成及生物活性研究进展

Progress in Synthesis,Bioactivities of Schiff Base and its Metal Complexes

席夫碱及其金属配合物具有独特的抗菌、抗肿瘤和抗氧化等生物活性。为筛选高效低毒的药物,人们合成了大量不同类型的席夫碱及其金属配合物并对其生物活性进行了研究。本文综述了近年来席夫碱及其金属配合物的合成,以及在抗菌、抗氧化、抗肿瘤等方面生物活性的研究进展,并为进一步研究其在医药领域的应用提供了信息支持。

Schiff base and its metal complexes have significant antimicrobial,antitumor and antioxidant activities. In order to screen the high-efficiency drugs with low toxicity,a large number of Schiff bases and their metal complexes have been synthesized,and the bioactivity screening of these ligands and complexes were performed. In present paper,the progress of synthesis,antimicrobial,antitumor and antioxidant activities of some kinds of Schiff bases and their metal complexes are reviewed.