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CHEK2基因突变与乳腺癌 被引量:1

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摘要 细胞周期调定点激酶基因(cell-cycle-chekpoint kinase gene,CHEK2)编码细胞周期调定点激酶,与BRCA1和P53参与的DNA修复有关,与乳腺癌发生有较密切的关系。我们应用PCR-SSCP技术检测CHEK2基因第1、10、11、13、14外显子的突变情况,现将结果报告如下。
出处 《中华普通外科杂志》 CSCD 北大核心 2009年第4期331-332,共2页 Chinese Journal of General Surgery
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参考文献4

  • 1Meijers-Heijboer H, Wijnen J, Vasen H, et al. The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. Am J Hum Genet, 2003, 72: 1308-1314.
  • 2Rajkumar T, Soumittra N, Nancy NK, et al. BRCA1, BRCA2 and CHEK2 (1100 del C) germline mutations in hereditary breast and ovarian cancer families in South India. Asian Pac J Cancer Prey, 2003,4:203-208.
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二级参考文献12

  • 1宋传贵,胡震,袁文涛,狄根红,沈镇宙,黄薇,邵志敏.中国上海家族性乳腺癌BRCA1和BRCA2基因的突变[J].中华医学遗传学杂志,2006,23(1):27-31. 被引量:29
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