摘要
细胞周期调定点激酶基因(cell-cycle-chekpoint kinase gene,CHEK2)编码细胞周期调定点激酶,与BRCA1和P53参与的DNA修复有关,与乳腺癌发生有较密切的关系。我们应用PCR-SSCP技术检测CHEK2基因第1、10、11、13、14外显子的突变情况,现将结果报告如下。
出处
《中华普通外科杂志》
CSCD
北大核心
2009年第4期331-332,共2页
Chinese Journal of General Surgery
参考文献4
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二级参考文献12
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1宋传贵,胡震,袁文涛,狄根红,沈镇宙,黄薇,邵志敏.中国上海家族性乳腺癌BRCA1和BRCA2基因的突变[J].中华医学遗传学杂志,2006,23(1):27-31. 被引量:29
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共引文献6
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1郑刚,魏玲,左文述.抑癌基因与乳腺癌的研究进展[J].中华肿瘤防治杂志,2007,14(17):1350-1353. 被引量:2
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2王忱,史玉荣,宁连胜,牛瑞芳,郝希山.天津地区家族性乳腺癌中CHEK2基因突变的研究[J].中华实验外科杂志,2008,25(3):401-401. 被引量:2
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3廖绍光,王雅杰.CHEK2基因与乳腺癌的关系[J].国际肿瘤学杂志,2011,38(6):447-449.
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5刘海峰,杨林,张文刚,郭宝峰.CHEK2单核苷酸多态性与乳腺癌的易感性[J].中国实用医刊,2016,43(21):11-14. 被引量:1
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7高裕,刘浩,李广永,李培军.CREPT、CyclinD1在肾透明细胞癌中的表达及意义[J].宁夏医科大学学报,2015,37(6):665-668. 被引量:1
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8王宁,王雅杰.细胞周期激酶CHEK2在早发性乳腺癌遗传易感性中的作用[J].医学研究杂志,2011,40(10):5-8. 被引量:2
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9万瑛,马少君,刘超,顾海勇,唐巍峰,董长青,丁国文,陈锁成.CHEK2基因多态性与食管癌淋巴结转移的关系[J].江苏大学学报(医学版),2011,21(5):405-408.
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10王宁,王雅杰.细胞周期激酶CHEK2和p53在恶性肿瘤细胞周期和凋亡中的作用[J].医学研究杂志,2012,41(9):4-6. 被引量:3