三组不同药物治疗突发性聋的疗效观察

Clinical study of sudden sensorineural hearing loss treated with three kinds of medicines

目的观察小剂量泼尼松、舒血宁治疗突发性聋的不同疗效;观察联合使用小剂量泼尼松和舒血宁是否可以提高疗效。方法2005年9月至2007年9月门诊突发性聋患者65例(67耳)。除外糖尿病患者。随机分成3组:第1组为激素治疗组,口服泼尼松30mg,每天早晨顿服,连续5天,以后每日减量5mg。共10天。第2组为舒血宁治疗组,舒血宁注射液20ml加入5%葡萄糖注射液250ml,静脉点滴,每日1次,共10天。第3组为激素加舒血宁治疗组联合使用泼尼松和舒血宁。分别在治疗前、治疗后检测纯音测听。结果激素治疗组有效率69.6%,舒血宁治疗组有效率63.0%,激素加舒血宁治疗组有效率68.2%,经检验3组疗效没有显著性差异。结论小剂量激素和舒血宁治疗突发性聋没有显著性差异,联合使用小剂量激素和舒血宁并不能提高疗效。

Objective To investigate the efficacy of prednisone and shuxuening（ Ginko biloba） and prednisone plus shuxuening for sudden sesorineural heating loss. Methods 65 patients （67 ears） with sudden sesorineural heating loss （SSHL） were divided into 3 groups ： group one were treated with prednisone 30mg/d for 5 days and tapered for five days; group two were treated with shuxuening intravenous 20ml/d for 10 days; group three were treated with prednisone 30mg/d plus shuxuening 20ml/d for 10 days. Results Heating improvement was observed in 16 of 23 patients who were treated with oral prednisone and in 14 of 22 patients who were treated with intravenous shuxuening and in 15 of 22 patients who were treated with shuxuening and prednisone. There was no significantly difference between 3 groups. Conclusion prednisone plus shuxuening had no better outcome than prednisone or shuxuening used alone.