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1,4-二脂肪氨基-5,8-二羟基蒽醌的合成及抗癌活性研究

Synthesis,characterization and anticancer activity of 1,4-bialiphatic amino-5,8-dihydroxy anthraquinones
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摘要 合成抗癌药物中间体脂肪胺取代的蒽醌类化合物,并对其进行体外抗癌活性测试.以1,4,5,8-四羟基蒽醌隐色体和脂肪胺为原料,在氮气保护下进行缩合反应,然后通过氧化合成目标化合物.对目标化合物利用红外光谱和核磁共振氢谱进行表征.体外抗癌活性测试表明化合物1,4-二[2-(二甲氨基)-乙氨基]-5,8-二羟基蒽醌有较强的抗癌活性. 1,4- Bialiphatic amino-5,8-dihydroxy anthraquinones as an intermediate of an anticancer drug were synthesized by the condensation and oxidation of leuco- 1,4,5,8- tetrahydroxyanthraquinone with aliphatic amine. Their structures were determined by FTIR and l H-NMR analysis. Anti-cancer activities of these compounds were roughly tested in vitro. Such 1,4- bi [ 2 ( dimethylamio ) -ethylamino ] - 5,8- dihydroxy-anthraquinone derivates made this a versatile strategy for the lead compound of anti-tumor drug.
出处 《天津理工大学学报》 2009年第2期1-3,共3页 Journal of Tianjin University of Technology
基金 国家自然科学基金(20376063) 天津市自然科学基金(043610511)
关键词 1 4 5 8-四羟基蒽醌隐色体 抗癌药物 药物合成 脂肪胺 leuco- 1,4,5,8- tetrahydroxyanthraquinone antitumor drug chemical synthesis aliphatic amine
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参考文献7

  • 1Denny W A,Wilon W R,Hay MP.Recent developmentsin the design of bioreductive drugs[].British Journal of Cancer.1996
  • 2Patterson L H,Mckeown S R.AQ4N:a new approach tohypoxia-activated cancer chemotherapy[].British Jour-nal of Cancer.2000
  • 3Keith C.Murdock,Pearl River.1,4-Bis(substituted-ami-no)-5,8-dihydroxyanthraquinones and leuco bases there-of[].US.1980
  • 4L.H. Patterson,SR Mckeown,K Ruparelia.Enhancement of chemotherapy and radiotherapy of murine tumours by AQ4N,a bioreductiely activated anti-tumour agent[].British Journal of Cancer.2000
  • 5Bronwyn G S,Kevin O H,Susan MP.Comparision of ar-omatic and tertiary amine N-oxide of acridine DNA inter-calaters as bioreductive drugs[].Biochemical Pharma-cology.2000
  • 6Phillips RM,Jaffar M,Maitland DJ, et al.Pharmacological and biological evaluation of a series of substituted 1,4-naphthoquinone bioreductive drugs[].Biochemical Pharmacology.2004
  • 7Laurence Hylton Patterson.Anthraquinone Anti-Cancer Compounds with(Disubstituted-Amino-N-Oxide)Alkylamino Substituent[].GB.1991

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