颞叶癫痫患者的心血管功能变化及相关因素分析

Analyze the related factors and the change of cardiovascular function of temporal epilepsy patients

目的分析30例颞叶癫痫患者的临床表现及心血管功能变化,同时测定患者血浆NE、DA、5-HT水平,证实颞叶癫痫患者存在心血管活动变化并探讨其发生机制。方法详细分析30例颞叶癫痫患者的临床表现、心电图改变及心肌酶学含量变化,同时采用荧光分光光度法检测血浆NE、DA、5-HT含量变化并与非颞叶癫痫患者及正常对照组进行统计学分析。结果(1)颞叶癫痫患者的临床表现复杂,发作形式多变;30例颞叶癫痫患者18例心电图有改变(60%),CK、LDH颞叶癫痫患者较非颞叶癫痫患者高(P<0.05);非颞叶癫痫患者心肌酶与正常对照组比较无统计学差异(P>0.05)。(2)颞叶癫痫患者发作间期血浆NE、5-羟色胺高于非颞叶癫痫组及正常对照组(P<0.05);颞叶癫痫患者血浆DA低于非颞叶癫痫组及正常对照组(P<0.05)。结论颞叶癫痫患者发作形式多样,临床表现复杂,存在心血管功能变化,并与神经递质相关。

Objective To analyze clinical manifestation,the change of cardiovascular function of 30 temporal epilepsy patients,and to determinate the level of norepinephrine,dopamine and 5-HT to verify that temporal epilepsy patients have cardiovascular function change,and to explore the mechanism.Methods To analyze clinical manifestation,electrocardiogram and cardiac creatase of 30 temporal epilepsy patients in detail.Fluorospectrophotometry was used to detect the change of plasma norepinephrine,dopamine and 5-HT.Then a statistical analysis was performed.Results （1）Temporal epilepsy patients＇ clinical manifestation was complex,seizure pattern was diversified.18 out of 30 60% temporal epilepsy patients had electrocardiographic change;creatinkinase,lactic dehydrogenase in temporal epilepsy patients are higher than non- temporal epilepsy patient, have statistical difference;but cardiac creatase between non-temporal epilepsy patient and normal control group has no difference;（2）Plasma norepinephrine and 5-HT in temporal epilepsy patients when no seizure were higher than non-temporal epilepsy patient which showed normal control group, had showed statistical difference;dopamine in temporal epilepsy patients were lower than non-temporal epilepsy patient and normal control group,had showed statistical difference.Conclusions Temporal epilepsy patients＇ have compler clinical manifestation, seizure pattern,and can co-exist with cardiovascular simultaneously function change.Which may bu related to neurotransmitter.