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血红蛋白和血红素氧合酶抑制剂在脑出血迟发性脑水肿中的作用 被引量：2

The role of hemoglobin and heme oxygenase inhibitor in delayed brain edema of ICH
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摘要 目的研究血红蛋白(Hb)与脑出血迟发性脑水肿的关系,锌原卟啉(ZnPP)在脑出血迟发性脑水肿中的作用,为治疗脑出血迟发性脑水肿提供新的方法。方法将大鼠分为生理盐水组、血红蛋白组和ZnPP组,向大鼠的尾状核分别注入生理盐水(NS组)和自体Hb溶液(Hb组和ZnPP组),并向ZnPP组大鼠腹腔内注射ZnPP,观察各组血脑屏障(BBB)通透性的变化、Hb的分解情况、脑水肿的程度和脑组织病理表现。结果与Hb组大鼠相比,ZnPP组大鼠BBB通透性降低、Hb的分解产物减少和脑含水量降低(P<0.05)。结论Hb可以引起脑水肿,ZnPP对脑出血迟发性脑水肿有治疗作用。 Objective To study the relationship between hemoglobin and delayed brain edema after intracerebral hemorrhage（ ICA） and the role of ZnPP in delayed brain edema,in order to provide a new method for the treatment of brain edema.Methods The rats were divided into 3 groups （group NS/group Hb/group ZnPP）,saline （group NS） or auto hemoglobin （group Hb and group ZnPP） was given to the right caudate nucleus of the rats. The change of the BBB permeability, the breakdown of the hemoglobin,the extent of brain edema and pathological appearance of brain tissue were observed.Results The BBB permeability, the degradations of hemoglobin and brain water content of group ZnPP were lower than that of group Hb （ P 〈0.05）.Conclusion Hemoglobin can cause brain edema, and ZnPP plays a role in treatment of the delayed brain edema of ICH.
作者 石艳超 周广喜
机构地区 天津医科大学总医院神经病学研究所 天津港口医院
出处 《中风与神经疾病杂志》 CAS CSCD 北大核心 2009年第2期219-221,共3页 Journal of Apoplexy and Nervous Diseases
关键词 血红蛋白 ZNPP 迟发性脑水肿 脑出血 Hemoglobin Heme oxygenase inhibitor Delayed brain edema ICH
分类号 R743.34 [医药卫生—神经病学与精神病学]
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参考文献10

  • 1Xi G, Keep RF, Hoff JT. Pathophysiology of brain edema formation [ J]. Neumsurg Clin N Am,2002,13:371- 383.
  • 2乐宏元,宋小兴,刘和平.一氧化碳血红蛋白双波长定量测量[J].临床检验杂志,1996,14(2):87-88. 被引量：92
  • 3Nau R. Osmotherapy for elevated intracerebral pressure: a critical reappraisal[ J ]. Clin Pharmacokinet ,2000,38 ( 1 ) :23-40.
  • 4Huang FP, Xi G, Keep RF, et al. Brain edema after experimental intracerebral hemorrhage: role of hemoglobin degradation products[J]. J Neurosurg,2002,96:287-293.
  • 5孟庆伟,郭景红,刘春梅.红细胞致脑出血后血肿周围脑组织HO-1的表达与血脑屏障通透性变化的关系[J].中风与神经疾病杂志,2006,23(6):741-742. 被引量：2
  • 6Ostrow JD, Pascolo L, Brites D, et al. Molecular basis of bilirubin induced neurotoxicity[ J]. Trends Mol Med, 2004, 10:65-70.
  • 7Hua Y, Nakalllura T, Keep RF, et al. Long-term effects of experimental intracerebral hemorrhage: the role of iron [ J ]. J Neurosurg, 2006,104(2 ) :305-312.
  • 8Wang J, Dore S. Heme oxygenase-1 exacerbates early brain injury after intracerebral haemorrhage [ J ]. Brain,2007,130 ( 6 ) : 1643-1652.
  • 9Zhuo M, Laitlnen JT, Li XC, et al. On the respective roles of nitric oxide and carbon monoxide in long-term potentiation in the hippo- campus[ J]. Learn Mem, 1999,6( 1 ) :63-76.
  • 10Gong Y,Tian H, Xi G, et al. Systemic zinc protoporphyrin administration reduces intracerebral hemorrhage-induced brain injury [ J ]. Acta Neurochir Suppl,2006 ,96 :232-236.

二级参考文献13

  • 1朱忠勇，实用医学检验学，1991年
  • 2林其燧，临床化学诊断方法大全，1990年
  • 3徐晓利，生物化学，1988年
  • 4Xi G,Keep RF,Hoff JT. Erythrocytes and delayed brain edema formation following intracerebral hemorrhage in rats[J]. J Neu rosurg, 1998,89: 991-996.
  • 5Huang F,Xi G, Keep RF, et al. Brain edema after experimental intracerebral hemorrhage:role of hemo-globin degradation products[J]. J Neurosurg, 2002,96 : 287-293.
  • 6Malnes MD. The heme oxygenase system and its functions in the brain[J]. Cell Mol Biol,2000,46:573-585.
  • 7Xue MZ,Marc R,Del Bigio. Intracerebral injection of autologous whole blood in rat :time course of inflammation and cell death[J]. Neuroscience Letters, 2000,283:230-232.
  • 8Mixter RC,Carson LV, Walton BJ,et al. Treatment of Nevus of Ota with the Candela PLTL lasers [J]. Plast Recenstr Surg, 1996,98:1112.
  • 9Bhasin RR,Xi G ,Hua Y,et al. Experimental intracerebral hemorrhagex effect of lysed erythrocytes on edema and blood-berrier permeability[J]. Acta Neurochir Suppl,2002,81 : 249-251.
  • 10Keyse SM,Tyrrell RM. Induction of the heine oxygenase gene in human skin fibrohlasts by hydrogen peroxide and UVA (365nm) radiation: evidence for the involvement of the hydroxyl radical [J]. Carcinogenesis, 1990,11: 787-791.

共引文献92

同被引文献26

  • 1张冠壮.脑出血并发迟发性脑水肿的相关因素分析[J].山东医药,2010,50(50):88-89. 被引量：9
  • 2Wagner KR, Dwyer BE. Hematoma removal, heme, and heme oxygenase following hemorrhagic stroke. Ann N Y Acad Sci, 2004, 1012: 237-251.
  • 3Xi G, Wagner KR, Keep RF, et al. Role of blood clot formation on early edema development after experimental intracerebral hemorrhage. Stroke, 1998, 29: 2580-2586.
  • 4Figueroa BE, Keep RF, Betz AL, et al. Plasminogen activators potentiate thrombin-induced brain injury. Stroke, 1998, 29: 1202- 1208.
  • 5Naff N J, Wemmer J, Hoenig-Rigamonti K, et al. A longitudinal study of patients with venous malformations: documentation of a negligible hemorrhage risk and benign natural history. Neurology, 1998, 50: 1709-1714.
  • 6Xi G, Hua Y, Bhasin RR, et al. Mechanisms of edema formation after intracerebral hemorrhage: effects of extravasated red blood cells on blood flow and blood-brain barrier integrity. Stroke, 2001,32: 2932- 2938.
  • 7Bhasin RR, Xi G, Hua Y, et al. Experimental intracerebral hemorrhege: effect of lysed erythrocytes on brain edema and blood-brain barrier permeability. Acta Neurochir Suppl, 2002, 81: 249-251.
  • 8Lain FA, Kahn SA, da Fonseca AC, et al. On the fate of extracellular hemoglobin and heme in brain. J Cereb Blood Flow Metab, 2009, 29: 1109-1120.
  • 9Song S, Hua Y, Keep RF, et al. A new hippocampal model for examining intracerebral hemorrhage-related neuronal death: effects of deferoxamine on hemoglobin-induced neuronal death. Stroke, 2007, 38:2861-2863.
  • 10Bao X, Wu G, Hu S, et al. Poly(ADP-ribose) polymerase activation and train edema formation by hemoglobin after intracerebral hemorrhage in rats. Acta Neurochir Suppol, 2008, 105: 23-27.

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中风与神经疾病杂志
2009年 第2期

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