肠易激综合征的病因及发病机制

Etiological Factor and Pathogenic Mechanism of Irritable Bowel Syndrome

肠易激综合征（IBS）是一种生物-心理-社会病症,其病因及发病机制仍未完全明了。主流观点认为是由于遗传（基因）和环境（如社会压力）等因素造成中枢神经和肠神经丛的调节失衡,从而导致胃肠动力和内脏感觉异常,引起症状。IBS是一种多因素引起的功能性疾病,目前对其病因和发病机制的研究已从多方面开展,并提出不同观点,如遗传因素、胃肠运动异常、内脏高敏感性、炎症和免疫因素、消化道激素及心理因素等。

hritable bowel syndrome is a biological-psychological-social disease, and its etiopathogenisis and pathogenesis are still not fully understood. Mainstream view is that genetic （gene） and environ- mentalfactor （such as social pressure） result in the disbalance of central nervous and intestinal plexus, and then lead to abnormality of gastrointestinal motility and visceral sense, which ultimately cause symptoms. Irritable bowel syndrome is a functional disease, which is caused by some factors. At present, the research about its etiopathngenisis and pathogenesis has been carried out in many ways, and some different points are presented, such as genetic factor, abnormality of gastrointestinal motility, visceral hypersensitivity, inflammatory and immunological factor, gastrointestinal hormones, psychosocial factors, and so on.