期刊文献+

癫痫发生的分子机制研究进展 被引量:1

原文传递
导出
摘要 癫痫是严重危害人类健康的神经系统常见病,以大量神经元反复发作的异常放电引起中枢神经系统短暂性功能失常为主要特征。病因多样,机制复杂。截至目前,癫痫治疗虽然取得了很大进展,但是手段仍然十分有限,且只能控制癫痫发作,却不能从根本上遏制疾病的发生或者完全根治疾病。因此,深入了解癫痫发生的分子机制,将为寻找更加精确、有效的治疗靶点,从而对存在高危因素的个体进行早期针对性干预,进而阻止疾病发生提供帮助。
出处 《中华儿科杂志》 CAS CSCD 北大核心 2009年第5期354-357,共4页 Chinese Journal of Pediatrics
  • 相关文献

参考文献19

  • 1Papazian DM, Schwarz TL, Tempel BL, et al. Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila. Science, 1987, 237: 749-753.
  • 2Rusconi R, Scalmani P, Cassulini RR, et al. Modulatory proteins can rescue a trafficking defective epileptogenic Navl. 1 Na^+ channel mutant. J Neurosci, 2007, 27 : 11037-11046.
  • 3Uehara A, Nakamura Y, Shioya T, et al. Altered KCNQ3 potassium channel function caused by the W309R pore-helix mutation found in human epilepsy. J Membr Biol, 2008, 222 : 55- 63.
  • 4Eugene E, Depienne C, Baulac S, et al. GABA (A) receptor gamma 2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition. J Neurosci, 2007, 27 : 14108-14116.
  • 5Berkovic SF, Mulley JC, Scheffer IE, et al. Human epilepsies: interaction of genetic and acquired factors. Trends Neurosci, 2006, 29 : 391-397.
  • 6Avanzini G, Franceschetti S, Mantegazza M. Epileptogenic channelopathies: experimental models of human pathologies. Epilepsia, 2007, 48 (Suppl 2): 51-64.
  • 7Glasscock E, Qian J, Yoo JW, et al. Masking epilepsy by combining two epilepsy genes. Nat Neurosci, 2007, 10: 1554- 1558.
  • 8Hanna MG. Genetic neurological channelopathies. Nat Clin Pract Neurol, 2006, 2: 252-263.
  • 9Pitkanen A, Kharatishvili I, Karhunen H, et al. Epileptogenesis in experimental models. Epilepsia, 2007, 48 ( Suppl 2) : 13-20.
  • 10Bender RA, Baram TZ. Epileptogenesis in the developing brain: what can we learn from animal models.'? Epilepsia, 2007, 48 ( Suppl 5 ) : 2-6.

同被引文献4

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部