老年心力衰竭患者的心肌氧化损伤及冠心宁的抗氧化疗效观察

Effect of perhexlline Injection on oxygen free radical in old patients with heart failure

目的观察冠心宁注射液对老年心力衰竭（CHF）患者氧自由基的影响。方法58例CHF患者，随机分为常规治疗组和冠心宁治疗组各29例，选取32例健康体检者作为对照。冠心宁组在常规治疗基础上加用冠心宁注射液治疗14d，观察其血浆中丙二醛（MDA）、血清总抗氧能力（TAOC）、氧化型低密度脂蛋白胆固醇（OX-LDL-C）、血清超氧化物歧化酶（SOD）的变化。结果58例CHF患者血清MDA[（5．59±1．95）μmoL／L]和OX-LDL-C[（808．64±156．34）μg／L]水平明显高于对照组[（4．04±0．67）μmol／L与（538．67±125．43）μg／L]（P〈0．05），SOD[（68．69±20．43）μU／L]、TAOC[（7．72±2．13）kU／L]显著低于对照组[（105．67±13．86）μU／L与（9．68±1．86）kU／L]（P〈0．05），心功能Ⅱ、Ⅲ、Ⅳ级CHF患者SOD、MDA、OX-LDL—C和TAOC差异均有统计学意义（F分别为18．86、10．63、25．57和11．27，P均〈0．05）。治疗14d冠心宁组有效率为96．6％（28／29），高于常规治疗组（79．3％，23／29），差异有统计学意义（x^2=6．41，P〈0．05）。结论冠心宁对CHF患者的治疗作用可能与其促进机体氧自由基的清除有关。

Objective To investigate the effect of perhexiline injection on oxygen free radical in old patients with heart failure（CHF）. Methods 32 healthy persons were taken as controls. 58 old patients with CHF were randomly divided into two groups. The treatment group received both basic therapy and perhexiline injection transfusion for 14 days. Malondialdehyde （MDA）, total antioxygen capacity （TAOC）, oxidation-low-density-lipoprotein-cholesterol （OX-LDL-C） and superoxide dismutase （SOD） were measured before the therapy and after the therapy. Results MDA [ （5.59 ± 1.95 ） μmoL/L and OX-LDL-C [ （808.64 ± 156.34 ）μg/L ] were significantly higher in the old patients with CHF] than control group[ （4.04 ± 0.67 μmol/L ） and （538.67 ± 125.43 ） μg/L] （ P 〈 0.05 ） ; SOD [ （68.69 ± 20.43 ）μU/L] and TAOC [ （7.72 ± 2.13 ）kU/L] were significantly lower in the old patients with heart failure than the matched group [ （105.67 ± 13.86）μU/L and （9.68 ±1.86）kU/L ] （P 〈 0.05 ）, which were positively associated with CHF severity. After the improvement of the cardiac function, MDA, OX-LDL-C, SOD and TAOC recovered significantly. Conclusion The therapeutic action of perhexiline injection in old patients with CHF can rely on the promotion of eliminating oxygen free radical inside organism.