灯盏花抗肝纤维化作用的研究进展

Effectiveness of Erigeron breviscapus against hepatic fibrosis

肝纤维化是许多慢性致病因素作用于肝脏,以细胞外基质在肝脏内沉积为特征,是慢性肝病发展到肝硬化、肝癌的必经途径。寻找有效的抗肝纤维化药物是近年研究的热点,其中对灯盏花的研究也取得了一定进展。现就近几年灯盏花对肝星状细胞增殖和凋亡、细胞外基质合成的影响等方面的研究做一综述。

Hepatic fibrosis is an essential pathological process involved in various chronic hepatic diseases, and its character is the deposition of extracellular matrix. It may deteriorate into hepatic cirrhosis and hepatic cancer. Thus, it has become hot topics to seek bioactive components against hepatic fibrosis. Some researches found that Erigeron breviscapus has the potential to be a bioactive agent against hepatic fibrosis. This review summarizes the research findings that Erigeron breviscapus affects the generation and apoptosis of hepatic stellate cells and synthesis of extracellular matrix and so on.