慢性肾功能衰竭与慢性炎症反应的关系

The Chronic Inflammatory Status in Patients with Chronic Renal Failure

目的:深入研究慢性炎症反应与慢性肾功能衰竭的关系。方法:将2001年6月至2004年6月在我院住院的慢性肾功能衰竭(CRF)患者126例分为4组,检测其血肌酐(Scr)、肌酐清除率(Ccr)、C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)。CRP、IL-10采用ELISA法测定,IL-6采用放射免疫法测定。结果:CRF患者各期的CRP、IL-6、IL-10水平均增高,与对照组比较,差异均有非常显著性(P<0.01);CRF患者CRP、IL-6、IL-10与血肌酐呈正的直线相关关系,与肌酐清除率呈负的直线相关关系;急性时相蛋白CRP、炎性介质IL-6与抗炎介质IL-10均有相关性。结论:CRF患者急性时相蛋白CRP、致炎性介质IL-6及抗炎性介质IL-10水平增高且随着肾功能损害程度的加重,急性时相蛋白CRP、致炎性介质IL-6及抗炎性介质IL-10水平进一步增高;急性时相蛋白CRP、致炎性介质IL-6与抗炎性介质IL-10有一定的相关性。

To study the relationship between the status of chronic inflammation and deterioration of renal function in patients with ehronic renal failure. Methods： Serum CRP. （with EIJSA） ,IL-10 （with ELISA） ,IL-6 （with RIA） ,and creatinine （with bio-chemistry） levers were determined in 126 patients with CRF of various stages who had been under tbe treatment in our hospital from June 2001 to June 2004.Results： In all these pa- tients, the serum CRP, IL-6,1L-10 levers were significantly higher than those in the controls （P〈0.01） . CRP,IL-6,IL-10 levers were linearly positively correlatod with the creatiniue levels, linearly negatively correlated with the creatinine clearance rate. Both the acute phase protein CRP and inflammatory cytokines IL-6 levels, were correlatod with anti- inflamatory cytokiues IL-10 level. Conclusion： The serum CRP, IL-6, IL-10 levers increased n these patients with CRF ,and gradually further increased ahmg with the progression of CRF. The acute phase protein CRP, inflammatory cytokines IL-6 were to certain extent correlated with anti-inflamatory cytokines IL-10.