抑癌基因PTEN在宫颈癌组织中的表达及意义

Expression and Significance of Tumor Suppressor Gene PTEN in Uterine Cervix Cancer

目的研究抑癌基因PTEN在宫颈癌组织中的表达及临床意义。方法应用免疫组化的方法研究PTEN在50例宫颈癌组织，在65例CINⅠ，98例CINⅡ～Ⅲ，20例正常宫颈组织中的表达情况。结果PTEN在宫颈癌中阳性率为36％，CINI中为84．6％，CINⅡ～Ⅲ中为61．2％，正常宫颈组织中为100%，差异有显著性。结论PTEN异常表达可能与宫颈癌发生发展及预后有关。

Objective To study the significance of abnormal expressions of PTEN protein in cervical carcinogenesis. Methods The expression of PTEN in 20 cases with normal epithelium, 153 cases with cervical intraepithelial neoplasia and 50 cases with cervical carcinomas was detected by immunohistochemical S-P technique with anti-PTEN antibody. Results The positive rate of PTEN expression in 20 cases with normal cervical epithelium,65 cases with CTN Ⅰ , 98 cases with CIN Ⅱ and Ⅲ ,and 50 cases with cervical carcinoma was 100%,84. 6%,61. 2%and 36%, respectively, PTEN expression reduced progressively in carcinogenesis process from normal cervical epithelium to cervical intraepithelial neoplasia to cervical carcionoma. Conclusion The abnormal expression of PTEN may be assoicated with the tumorigensis,devel- opment, prognosis of cervical cancer.