异基因造血干细胞移植术后并发癫痫14例临床分析

Clinical Analysis of Epilepsy After Allogeneic Hematopoietic Stem Cell Transplantation(14 Cases)

目的:分析造血干细胞移植术后癫痫的发病原因,探讨防治措施。方法:回顾性分析异基因造血干细胞移植218例临床资料,对术后并发癫痫患者的资料进行分析总结。结果:218例异基因造血干细胞移植术后发生癫痫14例,发病率为6.42%,死亡5例,病死率达35.7%;移植后癫痫的发生诱发因素为药物,颅内出血,水钠代谢失常及酸碱失调,糖尿病低血糖,感染及移植相关性血栓微血管病,移植物抗宿主病(GVHD)也常与癫痫相伴。结论:异基因造血干细胞移植术后患者并发癫痫预后差,积极处理诱发因素是防治癫痫最重要的措施。

Objective：To investigate the inducements of epilepsy and prevention measures after allogeneic hematopoietic stem cell transplantation. Methods：Retrospective analysis of allogeneic hematopoietic stem cell transplantation in 218 patients with clinical data,and clinical summary of patients with post operation epilepsy was made. Results：Out of 218 patients, 14 allogeneic hematopoietic stem cell transplant recipients suffered from epilepsy,with an incidence rate of 6.42%. 5 patients died after transplantation with a mortality rate of 35.7%, the incidence of epilepsy after transplantation for drug-induced factors,intracranial bleeding,salt and water metabolism disorders and acid-base disorders,diabetes,hypoglycemia,infection and transplantation thrombotic microangiopathy associated, graft versus host disease （GVHD） often associated with epilepsy were found. Conclusion： Allogeneic hematopoietic stem cell transplantation can induce epilepsy and may result in poor prognosis. Control of inducing factors is important in preventing and treating epilepsy.