心理干预联合舍曲林治疗老年抑郁症65例效果观察

A Comparative Study of Psychological Intervention with Sertraline in Elderly Patients with Depression(65Cases)

目的:观察心理干预联合舍曲林治疗老年抑郁症的效果。方法:将65例老年抑郁症患者随机分成两组,即研究组32例(采用心理干预联合舍曲林)和对照组33例(单用舍曲林),系统治疗8周;采用汉密顿抑郁量表(HAMD)评定疗效,不良反应症状量表(TESS)评定不良反应。结果:治疗第8周末,研究组总有效率为93.8%,对照组75.8%,两组差异有统计学意义(χ2=4.62,P<0.05);两组HAMD评分均较治疗前显著下降(P<0.01),研究组在2、6、8周末较对照组下降更显著(P<0.05,P<0.01)。两组治疗后各时段TESS评分比较差异均无统计学意义(P>0.05)。结论:心理干预联合舍曲林治疗老年抑郁症比单纯服用舍曲林起效快,疗效好。

Objective：To assess efficacy of psychiatherapy with Sertaline in the treatment of elderly depression. Methods：A total of 65 elderly patients with depression episoders were randomly devided into groups ;32 intervention cases received psychotherapy with Sertaline）and 33 control cases received Sertaline respectively for 8 weeks. Both of the two groups used Hamilton depression scale （HAMD） for evaluating efficacy and the Treatment Emergent Symptoms Scale （TESS） for evaluating side effects. Results：At the end of the 8th week of the study,the total effective rate of the study group was 93.8% , higher than 75.8% of the control group （ ~2 = 4.62,P 〈 0.05 ）. Compared with pretreatment,significant difference was found in both groups （P 〈 0.01 ）. The levels of depression were reduced. The scores of HAMD in the study group were significiantly lower than those in the control group （ P 〈 0.01 ）. At the end of Week 2nd ,6th, and 8th week, the scores of the study group were significantly lower than that of the control group （P 〈0.05 ,P 〈0.01 ） ,but there was no statistical significance between the postoperation scores of both the groups （ P 〉 0. 05 ）. Conclusion： Psychologial intervention combined with drug therapy is more effective than simple drug therapy in the treatment of elderly depression.