食管支架的应用及其生物相容性评价

Application and biocompatibility of esophageal scaffolds

随着诊疗水平的提高,需要行食管替代术的患者日益增多。食管支架材料的研究尝试了钛镍合金网、聚乙烯、高分子硅胶涤纶合成体、碳素纤维等高分子材料和部分生物材料,取得了一定成就。但由于这些材料不能很好地解决生物组织相容性和力学相容性等关键性问题,致使吻合口瘘、脱管及狭窄等并发症发生率很高,临床效果不佳。而利用组织工程技术对食管支架置入后进行评估是解决这些问题的希望,文章就此问题利用组织工程技术对食管支架材料的发展及应用进行探讨。

With the development of diagnosis and treatment, esophageal replacement is required by more and more patients. Esophageal scaffold materials are focus on titanium-nickel alloy, polyethylene, polymer silica gel terylene composite, carbon fiber and some biomaterials. However, those materials have poor biocompatibility and mechanical compatibility, resulting in high incidence of complications, such as anastomosis fistula, detachment of tube, and stenosis and poorly clinical effect. Whereas, implantation of esophageal scaffold is hopeful for solving the problems mentioned above. Here, we investigate the development and application of esophageal scaffold materials based on tissue engineering technique.