小口径人工血管表面的改性(英文)

Surface modification of small-diameter vascular prosthesis

当人工血管移植体内后,材料表面会吸附γ-球蛋白或纤维蛋白原,易于使血液中细胞成分如血小板黏附于表面,血小板一旦被吸附,可以变成扁平状而被激活,从而导致血小板不可逆聚集而产生血栓。在大于6mm口径人工血管移植中,有较高的血管通畅率,而在小口径人工血管(<6mm)移植中,由于低血流量状态,易形成血栓。因此有必要对小口径人工血管进行表面改性,增加血液相容性,主要改性方法有改变人工血管材料表面结构,增加人工血管表面内皮细胞黏附及人工血管材料表面的接技改性等。

Vascular prosthesis can absorb y-globulin or fibrinogen when they are transplanted in vivo, accordingly the cellular components in blood, such as platelet, are easy to attach on surface and become flat shape to be activated, which then result in an inreversible aggregation and thrombus formation. During the process of transplanting vascular prosthesis at a diameter of more than 6 mm, a high vascular patency rate can be observed, while small-diameter （〈 6 mm） vascular prosthesis transplantation is under low blood flow, therefore it produces the thrombosis. It is necessary to conduct surface modification of small-diameter vascular prosthesis and to enhance hemocompatibility. The main methods of modification include the alter of surface structure of vascular prosthesis, the augmentation of endothelial cells attachment on surface of vascular prosthesis, and grafting modification of vascular prosthesis surface.