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肾移植排斥反应的相关因子表达 被引量：5

Expression of factors associated with renal transplant rejection
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摘要 CD40通路在同种异体急性、慢性排斥反应的发生,发展过程发挥重要作用。进一步研究CD40通路的免疫学特性,将为探索早期监测预防和控制移植排斥反应开辟新的领域。sCD30作为CD30活化释放入血的活性成分,与CD30具有很好的相关性,在肾移植中sCD30的表达为移植肾急性排斥反应的早期诊断及其与急性肾小管坏死的鉴别提供了一个敏感性、特异性很高的非创伤性检查方法,并为指导术后免疫抑制治疗提供了依据。通过对以上肾移植排斥反应相关因子的研究,能有效预测和预防排斥反应,顺利解决移植免疫反应,提高肾脏移植的成功率和改善移植物远期存活。 CD40 pathway plays an important role in occurrence and development of acute and chronic allograft rejection. Further research on immune characteristics of CD40 pathway will explore new field for investigation of early monitoring, prevention and control of rejection, sCD30 as the active component of CD30 activation and release into blood has good correlation with CD30. Expression of CD30 provides a high sensitive and specific non-traumatic examination method for early diagnosis of acute rejection and its identification with acute tubular necrosis in renal transplantation. It also provides the basis for immunosuppressive therapy after transplantation. Through the above research on factor associated with renal transplant rejection the rejection can be effectively predicted and prevented, transplantation immunoreaction can be solved, successful rate of renal transplantation will be increased, and long-term survival of graft will be improved.
作者 邹本警 王赞涛 张永利
机构地区 辽河油田中心医院泌尿外科
出处 《中国组织工程研究与临床康复》 CAS CSCD 北大核心 2009年第18期3491-3494,共4页 Journal of Clinical Rehabilitative Tissue Engineering Research
关键词 肾移植 排斥 CD40 CD30
分类号 R617 [医药卫生—外科学]
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参考文献30

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二级参考文献28

  • 1Kahan BD. Potential therapoatic interventions to avoid or treat chronic allograft dysfunction. Transplantation,2001,71 :SS52.
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  • 4Guillot C, Guillonneau C, Mathieu P et al. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsiveness, but does not prevent chronic rejection. J Immunol,2002,168:1600.
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  • 9Vella JP, Magee C, Vos L et al. Cellular and humoral mechanisms of vascularized allograft rejection induced by indirect recognition of donor MHC allopeptides. Transplantation, 1999,67:1523.
  • 10Baker RJ, Hernandez-Fuentes MP, Brookes PA et al. Loss of direct maintenance of indirect alloresponses in renal allograft recipients: implications for the pathogenesis of chronic allograft nephropathy. J Immunol,2001,167:7199.

共引文献14

同被引文献82

引证文献5

二级引证文献5

中国组织工程研究与临床康复
2009年 第18期

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