局部5-ALA光动力疗法治疗脂溢性角化病的疗效观察

Efficacy of ALA-PDT in Treatment of Seborrheic Keratosis

目的观察局部5-ALA光动力疗法治疗面部脂溢性角化病的疗效和安全性。方法脂溢性角化病15例患者。将20%的5-ALA溶液浸润薄海绵片后覆盖面部皮损处,避光3h。移除湿敷海绵,用波长为635nm的激光照射病灶部位,能量密度120J/cm2,照射时间15～20min。治疗后10d、1个月复诊,评价治疗效果。结果治疗后10d,13例患者完全治愈,2例第2次治疗后1个月治愈。患者满意率为100.0%。结论局部5-ALA光动力疗法治疗脂溢性角化病疗效显著,美容效果理想,不良反应小。

Objective To evaluate the safety and efficacy of photodynamic therapy （PDT） using aminolevulinic acid （5-ALA） in the treatment of seborrheie keratosis（SK）. Methods A total of 15 patients with SK were treated with topical aminolevulinie acid photodynamic therapy （ALA-PDT）. Twenty percent of topical 5-ALA was applied to lesions with a 3 h incubation period and the skin of SK was treated with 120 J/cm^2 of 635 nm light from a diode laser for 15 to 20 minutes. Evaluation was performed by counting lesions at baseline, 10 days and 1 month after the beginning of the treatment. Before treatment and at each return visit, lesions were photographed. The therapy was determined to terminate or to continue depending on the change of lesions including color fading and flatting. In addition, patient＇s satisfaction was also investigated. Results At the given assessment time 10 days after PDT, 13 patients achieved complete healing. Two cases of SK revealed a 100. 0% clearance of lesions with another session 1 month after the beginning. The satisfaction rate of patients was 100% after ALA-PDT. Conclusions PDT, utilizing the topical administration of 20% 5-ALA, is significant effectively in the treatment of SK with excellent cosmetic results and less side effects. This therapy is available for all dermatologists to utilize in medical and cosmetic dermatologic surgery.