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多发性硬化症治疗新药研究进展 被引量：2

Progress in Study of New Drugs for Treatment of Multiple Sclerosis
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摘要 多发性硬化症(MS)是一种慢性脱髓鞘疾病。文章简要介绍多发性硬化症的特征。综述治疗MS的单克隆抗体—达克珠单抗及其临床疗效、脱氧核糖核酸疫苗—BHT3009的质粒构建和随机的安慰剂对照Ⅰ期、Ⅱ期临床试验以及减轻MS患者疼痛药物—sativex等新药研究进展。 The multiple sclerosis（MS）is a chronic demyelinating disease. In this paper, a brief introduction to the character of MS is described. Progress in study of new drugs, such as monclonal antibody-Daclizumab and its clinical efficacy, the construction of DNA vaccine-BHT-3009 and its randomized, pla2 cebo-controlled phase I and II trial and new analgesic-Sativex for treatment of MS was reviewed.
作者 陈执中
机构地区 复旦大学药学院
出处 《药物生物技术》 CAS CSCD 2009年第2期186-188,共3页 Pharmaceutical Biotechnology
关键词 多发性硬化症 达克珠单抗 脱氧核糖核酸疫苗 镇痛新药 Multiple sclerosis（MS）, Daclizumab, DNA vaccine, New analgesic
分类号 R593 [医药卫生—内科学] R9 [医药卫生—药学]
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参考文献11

  • 1Steinman L. Multiple sclerosis: a two-stage disease[J]. Nat Immunol, 2001, 2(9):762.
  • 2Sospedra M,Martin R. Immunology of Multiple sclerosis[J]. Annu Rev Immanol, 2005, 23..683.
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  • 6Bclckova B, Richert N, Howard T, et al. Humanized anti- CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interfern beta[J]. Proc Natl Acad Sci, 2004,101:8705.
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药物生物技术
2009年 第2期

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