子宫颈微偏腺癌的临床病理分析

目的:子宫颈微偏腺癌是女性生殖系统极少见的肿瘤,探讨其临床及病理形态特征、诊断要点、免疫表型特征,以提高诊断的准确性。方法:现报道5例诊断为宫颈微偏腺癌,对其临床病理形态学、免疫表型特征进行观察分析,并探讨其诊断和鉴别诊断。、结果:临床主要表现为阴道不规则流血及大量稀黏液性白带,宫颈肥大和糜烂。部分病例合并黑斑息肉综合征、子宫肌瘤或卵巢肿瘤。病理特征为腺体轻度增生,大小不一、形态不规则,有轻度异型性,腺体侵入宫颈壁8mm以上并有特殊间质反应、癌胚抗原有肯定的阳性反应。结论:诊断宫颈微偏腺癌应密切结合临床表现,提出宫颈腺体有无不典型增生,多取材并尽量深取组织(>5mm)或高频电刀锥切宫颈活检,可早期及时诊断,防止漏诊。

Objective：Uterine neck micr-unsymmetrical adencarcinoma is exceptional tumor of female reproductive system, We are able to elevate accuratissime of diagnosis for this disease through approaching its clinical and pathomorphologic characteristics,diacrisis highlight, immunologic manifestation feature. Methods we surveied and analyzed clinic, pathomorphologic,immunologic manifestation, diagnosis and antidiastole of five cases. Results Its main clinical appearances were vagina anomal bleeding, rheuma leucorrhea, cervical hypertrophy and anabrosis ; some cases merged black speck polypus syndrome, hysteromyoma or tumor of the ovary ; Its pathologic character was light accrementition of glandular organ with different size, anoma/ morphous, light heteromorphism, intrading into cervix wall over 8cm and special stromal reaction. And carcino - embryonic antigen had confirmed positive reaction. Conclusion On diagnosing uterine neck micr - unsymmetrical adencarcinoma, we should marriage clinical manifestation. Proposing cervical gland whether or not has atypical hyperplasia,repeatedly obtaining more sampie,deeply （ 〉5mm）getting tissue,or conically cutting cervical biopsy by high frequency electro surgical unit,can help us diagnose this disease early period and promptly,also prevent missed diagnosis.